Young Researchers and Elite Club, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Drug Discov Today. 2018 May;23(5):1152-1158. doi: 10.1016/j.drudis.2018.04.006. Epub 2018 Apr 13.
The biocompatibility and nontoxicity of nanodiamonds (NDs) in combination with their excellent physical performance have rendered them attractive candidates for biomedical applications. NDs have great potential in drug nanoformulations because of their small size compared with other carbon nanomaterials. They are nontoxic with excellent adsorption properties and can be formulated into skin care products. Even though NDs have shown encouraging potential in skin preparations, only a few studies have reviewed their application in topical drug delivery systems. Therefore, here we focus on the application of NDs in skin care preparations, skin cancer medication, and wound healing. We also highlight the development of topical drug delivery by NDs and their cytotoxicity.
纳米金刚石（NDs）具有良好的生物相容性和低毒性，以及出色的物理性能，使其成为生物医学应用的理想候选材料。与其他碳纳米材料相比，NDs 的尺寸较小，在药物纳米制剂中具有巨大的潜力。它们具有出色的吸附性能，并且毒性低，可以制成护肤品。尽管 NDs 在皮肤制剂中显示出了令人鼓舞的潜力，但只有少数研究综述了它们在局部药物传递系统中的应用。因此，在这里我们重点介绍 NDs 在护肤品、皮肤癌药物和伤口愈合中的应用。我们还强调了 NDs 对局部药物传递的发展及其细胞毒性。
