Wolf N S, Giddens W E, Martin G M
Department of Pathology, University of Washington, Seattle.
J Gerontol. 1988 May;43(3):B71-8. doi: 10.1093/geronj/43.3.b71.
We have utilized a long-lived (Af X C57BL/6)F1 hybrid strain of mice for a variety of aging studies. In this report we have characterized the life expectancy and pattern of spontaneous deaths in 202 mice, malignant and nonmalignant lesions in 64 male mice dying spontaneously, and organ weights and lesions in 39 male mice killed at selected ages. The maximum age observed was 41.5 months. The principal causes of death were malignant lymphoma and alveologenic neoplasms, which were present in 56.3% and 45.3%, respectively, of the mice dying spontaneously. A variety of other neoplastic and non-neoplastic lesions that are not infrequently seen in older mice were observed in these mice. Neoplasms seen in these mice that are rare in other mice included disseminated mast cell tumors in two mice and gastric adenocarcinoma in one mouse. In comparing the diseases observed in this hybrid strain with those reported for the parent strains, there was an incidence of malignant lymphoma similar to the C57BL/6 parent, an incidence of alveologenic neoplasms intermediate between the parent strains, and a markedly reduced incidence of amyloidosis. This study provides a detailed background of baseline hematologic and morphologic data in a long-lived hybrid of two commonly used strains of mice.
我们使用了一种长寿的（Af×C57BL/6）F1杂交系小鼠进行了各种衰老研究。在本报告中，我们描述了202只小鼠的预期寿命和自然死亡模式、64只自然死亡雄性小鼠的恶性和非恶性病变，以及在选定年龄处死的39只雄性小鼠的器官重量和病变情况。观察到的最大年龄为41.5个月。主要死亡原因是恶性淋巴瘤和肺泡源性肿瘤，分别占自然死亡小鼠的56.3%和45.3%。在这些小鼠中还观察到了老年小鼠中常见的各种其他肿瘤性和非肿瘤性病变。在这些小鼠中出现的在其他小鼠中罕见的肿瘤包括两只小鼠的弥漫性肥大细胞瘤和一只小鼠的胃腺癌。在将该杂交系小鼠中观察到的疾病与亲本系报道的疾病进行比较时，恶性淋巴瘤的发生率与C57BL/6亲本相似，肺泡源性肿瘤的发生率介于亲本系之间，淀粉样变性的发生率明显降低。本研究提供了两种常用品系小鼠的长寿杂交系中基线血液学和形态学数据的详细背景。
