School of Pharmacy, University of Mississippi, University, MS, United States of America.
Department of Pharmacy Administration, University of Mississippi, University, MS, United States of America.
PLoS One. 2020 Feb 13;15(2):e0228586. doi: 10.1371/journal.pone.0228586. eCollection 2020.
Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders of women of reproductive age. Treatment plans for this chronic condition frequently include long-term use of a combination of medication and lifestyle interventions. However, treatment outcomes are dependent on adherence to treatment regimens. This study aimed to systematically review the literature for reported adherence to treatments for PCOS.
A systematic search of Embase, Cochrane, PubMed, CINAHL, PsychINFO, SCOPUS, and International Pharmaceutical Abstracts from inception until January 2019 utilizing the terms PCOS, adherence, and patient compliance was conducted. A total of 179 possible articles were identified.
Fourteen articles reporting adherence data were included in the review. Self-report was the most commonly reported method of measuring adherence. Adherence to lifestyle interventions, such as prescribed diets and physical activity, was reported in ten studies and adherence to medications was reported in seven studies, with some reporting both.
Minimal data are available regarding factors associated with adherence in patients with PCOS. Diverse methods of adherence assessment are utilized. Future studies of PCOS treatments should effectively assess and report adherence data as it is essential to evaluating the effectiveness of PCOS treatments and is critically needed to guide clinician efforts to facilitate optimal outcomes for patients.
多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌疾病之一。这种慢性疾病的治疗方案通常包括长期使用药物和生活方式干预的组合。然而，治疗效果取决于对治疗方案的坚持。本研究旨在系统地回顾文献，以报告多囊卵巢综合征治疗的依从性。
从开始到 2019 年 1 月，使用术语 PCOS、依从性和患者依从性，对 Embase、Cochrane、PubMed、CINAHL、PsychINFO、SCOPUS 和国际药学文摘进行了系统搜索。总共确定了 179 篇可能的文章。
综述中纳入了 14 篇报告依从性数据的文章。自我报告是最常用的测量依从性的方法。有 10 项研究报告了生活方式干预（如规定的饮食和体育活动）的依从性，有 7 项研究报告了药物治疗的依从性，其中一些研究同时报告了这两种情况。
关于多囊卵巢综合征患者依从性相关因素的资料很少。依从性评估方法多种多样。未来对多囊卵巢综合征治疗的研究应有效地评估和报告依从性数据，因为这对于评估多囊卵巢综合征治疗的效果至关重要，并且对于指导临床医生努力为患者提供最佳结果也非常必要。
