Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Faculty of Applied Sciences, Universiti Teknologi MARA, 94300, Kota Samarahan, Sarawak, Malaysia.
Angew Chem Int Ed Engl. 2018 Jul 16;57(29):8854-8858. doi: 10.1002/anie.201800775. Epub 2018 Jun 19.
Supramolecular building blocks, such as cucurbit[n]uril (CB[n])-based host-guest complexes, have been extensively studied at the nano- and microscale as adhesion promoters. Herein, we exploit a new class of CB[n]-threaded highly branched polyrotaxanes (HBP-CB[n]) as aqueous adhesives to macroscopically bond two wet surfaces, including biological tissue, through the formation of CB[8] heteroternary complexes. The dynamic nature of these complexes gives rise to adhesion with remarkable toughness, displaying recovery and reversible adhesion upon mechanical failure at the interface. Incorporation of functional guests, such as azobenzene moieties, allows for stimuli-activated on-demand adhesion/de-adhesion. Macroscopic interfacial adhesion through dynamic host-guest molecular recognition represents an innovative strategy for designing the next generation of functional interfaces, biomedical devices, tissue adhesives, and wound dressings.
超分子建筑块，如基于葫芦[n]脲（CB[n]）的主客体配合物，已在纳米和微米尺度上作为黏附促进剂得到广泛研究。在此，我们利用一类新型的 CB[n] 穿线的高度支化聚轮烷（HBP-CB[n]）作为水基黏合剂，通过 CB[8] 杂三元配合物的形成，将两个湿表面（包括生物组织）宏观地黏合在一起。这些配合物的动态性质赋予了其显著的韧性黏附性，在界面发生机械失效时，能够实现恢复和可重复的黏附。功能客体（如偶氮苯部分）的掺入允许刺激触发的按需黏附和去黏附。通过动态主客体分子识别实现的宏观界面黏附为设计下一代功能界面、生物医学设备、组织黏合剂和伤口敷料提供了一种创新策略。
