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欧洲放射剂量学研究组织(EURADOS)在体内剂量学方面的工作。

EURADOS work on internal dosimetry.

作者信息

Breustedt B, Blanchardon E, Castellani C-M, Etherington G, Franck D, Giussani A, Hofmann W, Lebacq A-L, Li W B, Noßke D, Lopez M A

机构信息

a Karlsruhe Institute of Technology, Safety and Environment - Radioanalytical Laboratories, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

b Institut de Radioprotection et de Sûreté Nucléaire, France.

出版信息

Ann ICRP. 2018 Oct;47(3-4):75-82. doi: 10.1177/0146645318756232. Epub 2018 Apr 17.

Abstract

European Radiation Dosimetry Group (EURADOS) Working Group 7 is a network on internal dosimetry that brings together researchers from more than 60 institutions in 21 countries. The work of the group is organised into task groups that focus on different aspects, such as development and implementation of biokinetic models (e.g. for diethylenetriamine penta-acetic acid decorporation therapy), individual monitoring and the dose assessment process, Monte Carlo simulations for internal dosimetry, uncertainties in internal dosimetry, and internal microdosimetry. Several intercomparison exercises and training courses have been organised. The IDEAS guidelines, which describe - based on the International Commission on Radiological Protection's (ICRP) biokinetic models and dose coefficients - a structured approach to the assessment of internal doses from monitoring data, are maintained and updated by the group. In addition, Technical Recommendations for Monitoring Individuals for Occupational Intakes of Radionuclides have been elaborated on behalf of the European Commission, DG-ENER (TECHREC Project, 2014-2016, coordinated by EURADOS). Quality assurance of the ICRP biokinetic models by calculation of retention and excretion functions for different scenarios has been performed and feedback was provided to ICRP. An uncertainty study of the recent caesium biokinetic model quantified the overall uncertainties, and identified the sensitive parameters of the model. A report with guidance on the application of ICRP biokinetic models and dose coefficients is being drafted at present. These and other examples of the group's activities, which complement the work of ICRP, are presented.

摘要

欧洲辐射剂量测定小组(EURADOS)第7工作组是一个关于体内剂量测定的网络,汇集了来自21个国家60多个机构的研究人员。该小组的工作被组织成任务小组,专注于不同方面,如生物动力学模型的开发和实施(例如用于二乙烯三胺五乙酸促排疗法)、个人监测和剂量评估过程、体内剂量测定的蒙特卡罗模拟、体内剂量测定的不确定性以及体内微剂量测定。已经组织了几次比对试验和培训课程。该小组维护并更新了IDEAS指南,该指南基于国际放射防护委员会(ICRP)的生物动力学模型和剂量系数,描述了一种从监测数据评估体内剂量的结构化方法。此外,代表欧盟委员会能源总局(DG-ENER)制定了《职业性摄入放射性核素人员监测技术建议》(2014 - 2016年TECHREC项目,由EURADOS协调)。通过计算不同情景下的滞留和排泄函数对ICRP生物动力学模型进行了质量保证,并向ICRP提供了反馈。对最新的铯生物动力学模型进行的不确定性研究量化了总体不确定性,并确定了该模型的敏感参数。目前正在起草一份关于ICRP生物动力学模型和剂量系数应用指南的报告。本文展示了该小组活动的这些及其他实例,这些活动对ICRP的工作起到了补充作用。

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