IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.
PLoS One. 2018 Apr 17;13(4):e0195683. doi: 10.1371/journal.pone.0195683. eCollection 2018.
The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer.
Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis.
Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies. Considering hazard ratios, a statistically significant association was found for all cancers studied (1.14; CI 95%: 1.04, 1.24), digestive tract cancer (1.34; CI 95%: 1.05, 1.72), pancreatic cancer (1.74; CI 95%: 1.21, 2.52), prostate cancer (1.25; CI 95%: 1.04, 1.51), breast cancer (1.11; CI 95%: 1.00, 1.23), corpus uteri cancer (2.20; CI 95%: 1.16, 4.18), lung cancer (1.24; CI 95%: 1.06, 1.45), hematological cancer (1.30; CI 95%: 1.11, 1.53), esophagus / oropharyngeal cancer pooled together (2.25; CI 95%: 1.30, 3.90) and Non-Hodgkin lymphoma (1.30; CI 95%: 1.11, 1.52).
Despite the sparse scientific evidence and considering the low statistical power of the results, this systematic review revealed a substantial lack of studies with standardized and comparable methods to speculate about the association between periodontitis and cancer; more studies are need in order to explore further the scientific evidence of such correlation.
本系统评价的目的是评估牙周炎与癌症发展之间关联的假设。
两位审查员独立筛选电子和手工资源，以获取相关文章。主要结局指标是在暴露组和非暴露组中报告的肿瘤诊断发生率，以评估癌症与牙周炎之间的关联。
在最初检索到的 490 篇论文中，有 10 篇被纳入定性综合分析，8 篇被纳入定量综合分析；这 8 篇论文涵盖了 6 项研究。考虑到危险比，发现所有研究的癌症（1.14；95%CI：1.04，1.24）、消化道癌（1.34；95%CI：1.05，1.72）、胰腺癌（1.74；95%CI：1.21，2.52）、前列腺癌（1.25；95%CI：1.04，1.51）、乳腺癌（1.11；95%CI：1.00，1.23）、子宫体癌（2.20；95%CI：1.16，4.18）、肺癌（1.24；95%CI：1.06，1.45）、血液癌（1.30；95%CI：1.11，1.53）、食管/口咽癌汇总（2.25；95%CI：1.30，3.90）和非霍奇金淋巴瘤（1.30；95%CI：1.11，1.52）之间存在显著关联。
尽管科学证据有限，并且考虑到结果的统计效力较低，但本系统评价显示，存在大量缺乏标准化和可比方法的研究，无法推测牙周炎与癌症之间的关联；需要进一步研究以探索这种相关性的科学证据。
