2 型糖尿病的预防与治疗：基于病理生理学的方法。
Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach.
机构信息
Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia.
Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
出版信息
Trends Endocrinol Metab. 2018 Jun;29(6):370-379. doi: 10.1016/j.tem.2018.03.014. Epub 2018 Apr 14.
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes. Further studies incorporating 'omic' approaches to discover novel markers of phenotypes and treatment effectiveness may pave the way to personalizing the treatment of prediabetes and diabetes.
大约 40%的美国成年人患有前驱糖尿病。随机试验报告称，尽管进行了热量限制、体育锻炼，和/或使用一线药物二甲双胍治疗，一部分前驱糖尿病患者仍会发展为糖尿病。目前，尚无有效指标可预测这些措施在确定哪些人会、哪些人不会进展为 2 型糖尿病（T2DM）状态方面的有效性。少数研究探讨了临床和表型预测因素，以了解生活方式干预和二甲双胍治疗前驱糖尿病和糖尿病的血糖反应好坏。进一步结合“组学”方法的研究，以发现表型和治疗效果的新标志物，可能为个性化治疗前驱糖尿病和糖尿病铺平道路。
Zotero 插件