Tsuyuki Tomohisa, Kitamura Mineaki, Takatani Miho, Tsuji Kiyokazu, Torigoe Kenta, Tsuji Sosuke, Fujita Naruhiro, Yamaguchi Yutaka, Mukae Hiroshi, Nishino Tomoya
Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Department of Nephrology, Nagasaki Genbaku Hospital, Japan.
Intern Med. 2025 Aug 1;64(15):2361-2368. doi: 10.2169/internalmedicine.4747-24. Epub 2025 Feb 1.
A 78-year-old woman experienced systemic edema and was diagnosed with nephrotic syndrome and Hashimoto's thyroiditis (HT). A renal biopsy revealed minimal change disease (MCD) and tubulointerstitial nephritis, which resulted in the diagnosis of primary Sjögren's syndrome (PSS). PSS and HT can be complicated with MCD; however, there are no published case reports of MCD presenting with both conditions simultaneously. We aimed to inform nephrologists and rheumatologists about this rare condition through a literature review of renal outcomes in patients with MCD associated with PSS and HT.
一名78岁女性出现全身性水肿,被诊断为肾病综合征和桥本甲状腺炎(HT)。肾活检显示为微小病变病(MCD)和肾小管间质性肾炎,最终诊断为原发性干燥综合征(PSS)。PSS和HT可并发MCD;然而,尚无同时出现这两种疾病的MCD的病例报告发表。我们旨在通过对与PSS和HT相关的MCD患者的肾脏结局进行文献综述,让肾病学家和风湿病学家了解这种罕见疾病。