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果蝇遗迹hobo和hobo微型反向重复转座元件（hobo-MITEs）转座子作为新调控网络的原材料。

Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks.

作者信息

Loreto Elgion L S, Deprá Maríndia, Diesel José F, Panzera Yanina, Valente-Gaiesky Vera Lucia S

机构信息

Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Departamento de Bioquímica e Biologia Molecular (CCNE), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.

出版信息

Genet Mol Biol. 2018;41(1 suppl 1):198-205. doi: 10.1590/1678-4685-GMB-2017-0068. Epub 2018 Mar 26.

DOI:10.1590/1678-4685-GMB-2017-0068
PMID:29668013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5913719/
Abstract

Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.

摘要

对拟暗果蝇的高变异性菌株已经研究了20年。分离并鉴定了几个突变体，其中一些具有与发育改变相关的表型；例如，显示出异位腿，且眼睛代替触角表达。这种高变异性的致病因子是一种非自主的与hobo相关的序列（hoboVA）。在拟暗果蝇基因组中存在大约100个可移动的该元件拷贝，并且这些拷贝可能由自主且典型的hobo元件进行移动。我们已经表明，hoboVA具有发育基因驼背蛋白和偶数缺口蛋白的转录因子结合位点，并且该转座子在胚胎中按照这些基因的模式表达。我们认为，hobo和与hobo相关的元件可以成为新调控网络出现的物质基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/7fec9c0ceb60/1415-4757-GMB-41-01-2017-0068-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/83ca199036ba/1415-4757-GMB-41-01-2017-0068-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/aa71eb45b0c4/1415-4757-GMB-41-01-2017-0068-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/1fbd50ef258c/1415-4757-GMB-41-01-2017-0068-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/2e83db49e072/1415-4757-GMB-41-01-2017-0068-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/7fec9c0ceb60/1415-4757-GMB-41-01-2017-0068-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/83ca199036ba/1415-4757-GMB-41-01-2017-0068-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/aa71eb45b0c4/1415-4757-GMB-41-01-2017-0068-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/1fbd50ef258c/1415-4757-GMB-41-01-2017-0068-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/2e83db49e072/1415-4757-GMB-41-01-2017-0068-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b210/5913719/7fec9c0ceb60/1415-4757-GMB-41-01-2017-0068-gf05.jpg

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2
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Involvement of DNA Repair Genes and System of Radiation-Induced Activation of Transposons in Formation of Transgenerational Effects.
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Front Genet. 2020 Nov 27;11:596947. doi: 10.3389/fgene.2020.596947. eCollection 2020.
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"What You Need, Baby, I Got It": Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila.“宝贝，你需要的，我都有”：转座元件作为果蝇顺式作用序列的供应者
Biology (Basel). 2020 Feb 3;9(2):25. doi: 10.3390/biology9020025.
5
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PLoS One. 2019 Oct 17;14(10):e0220539. doi: 10.1371/journal.pone.0220539. eCollection 2019.
Genome Biol. 2016 May 9;17:100. doi: 10.1186/s13059-016-0965-5.
4
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BMC Genomics. 2016 Mar 8;17:201. doi: 10.1186/s12864-016-2519-3.
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6
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7
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