大气污染对老年人冬季户外活动心肺影响的队列研究。
Cardiorespiratory Effects of Air Pollution in a Panel Study of Winter Outdoor Physical Activity in Older Adults.
机构信息
Population Studies Division, Health Canada, Vancouver, British Columbia and Ottawa, Ontario (Dr Stieb, Dr Shutt, Dr Kauri, Dr Szyszkowicz, Dr Chen, Jovic, Dr Liu, Dr Dales), School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario (Dr Stieb), British Columbia Ministry of Environment and Climate Change Strategy, Prince George, British Columbia (Ms Roth), Air Health Science Division, Health Canada, Vancouver, British Columbia and Ottawa, Ontario (Ms Dobbin, Mr Van Ryswyk, Mr Kulka, Dr Weichenthal), Hazard Identification Division, Health Canada, Ottawa, Ontario (Mr Rigden, Dr Pelletier), University of Ottawa Heart Institute, Ottawa, Ontario (Ms Mulholland, Dr Green), Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec (Dr Weichenthal), and Department of Medicine, University of Ottawa, Ottawa, Ontario (Dr Dales), Canada.
出版信息
J Occup Environ Med. 2018 Aug;60(8):673-682. doi: 10.1097/JOM.0000000000001334.
OBJECTIVE
The aim of this study was to assess cardiorespiratory effects of air pollution in older adults exercising outdoors in winter.
METHODS
Adults 55 years of age and older completed daily measurements of blood pressure, peak expiratory flow and oximetry, and weekly measurements of heart rate variability, endothelial function, spirometry, fraction of exhaled nitric oxide and urinary oxidative stress markers, before and after outdoor exercise, for 10 weeks. Data were analyzed using linear mixed effect models.
RESULTS
Pooled estimates combining 2014 (n = 36 participants) and 2015 (n = 34) indicated that an interquartile increase in the Air Quality Health Index was associated with a significant (P < 0.05) increase in heart rate (0.33%) and significant decreases in forced expiratory volume (0.30%), and systolic (0.28%) and diastolic blood pressure (0.39%).
CONCLUSION
Acute subclinical effects of air pollution were observed in older adults exercising outdoors in winter.
目的
本研究旨在评估冬季在户外锻炼的老年人暴露于空气污染时的心肺影响。
方法
55 岁及以上的成年人在户外锻炼前后，每天测量血压、呼气峰值流量和血氧饱和度，每周测量心率变异性、内皮功能、肺活量、呼气一氧化氮分数和尿液氧化应激标志物，共 10 周。使用线性混合效应模型进行数据分析。
结果
结合 2014 年（n = 36 名参与者）和 2015 年（n = 34 名）的数据进行汇总估计，表明空气质量健康指数每增加一个四分位距与心率显著增加（0.33%）和用力呼气量显著减少（0.30%）、收缩压（0.28%）和舒张压（0.39%）相关。
结论
在冬季在户外锻炼的老年人中观察到空气污染的急性亚临床影响。
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