心外膜脂肪组织与代谢综合征：系统评价和荟萃分析的更新方案

Epicardial adipose tissue and metabolic syndrome: An update protocol for systematic review and meta-analysis.

作者信息

Roever Leonardo, Resende Elmiro Santos, Diniz Angélica Lemos Debs, Penha-Silva Nilson, O'Connell João Lucas, Gomes Paulo Fernando Silva, Zanetti Hugo Ribeiro, Roerver-Borges Anaisa Silva, Veloso Fernando César, Souza Fernanda Rodrigues de, Duarte Poliana Rodrigues Alves, Fidale Thiago Montes, Casella-Filho Antonio, Dourado Paulo Magno Martins, Chagas Antonio Carlos Palandri, Ali-Hasan-Al-Saegh Sadeq, Reis Paulo Eduardo Ocke, Pinto Rogério de Melo Costa, Oliveira Gustavo B F, Avezum Álvaro, Neto Mansueto, Durães André, Silva Rose Mary Ferreira Lisboa da, Grande Antonio José, Denardi Celise, Lopes Renato Delascio, Nerlekar Nitesh, Alizadeh Shahab, Hernandez Adrian V, Rosa Maria Inês da, Biondi-Zoccai Giuseppe

机构信息

Federal University of Uberlândia, Department of Clinical Research, Master Institute of Education President Antonio Carlos, IMEPAC, Araguari Department of Clinical Research, HCFMUSP - University of São Paulo Medical School, Department of Cardiology Faculty of Medicine ABC, Department of Cardiology Santo André Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Department of Cardiology, Yazd, Iran Department of Specialized and General Surgery, Fluminense Federal University, Rio de Janeiro Dante Pazzanese Institute of Cardiology, Department of Clinical Research, São Paulo Graduate Program in Medicine and Health, Department of Health and Sciences, Federal University of Bahia Federal University of Minas Gerais, Department of Cardiology, MG Federal University of Mato Grosso, Department of Medicine, MT FOP Unicamp, Department of Clinical Research, SP Division of Cardiology, Duke University Medical Center, Department of Clinical Research, Durham, NC Monash Cardiovascular Research Centre and MonashHeart, Department of Cardiology, Clayton, Victoria, Australia Department of Medicine, Tehran University of Medical Sciences University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, Department of Comparative Effectiveness and Outcomes Research Health Outcomes, CT Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciúma, Brazil Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.

出版信息

Medicine (Baltimore). 2018 Apr;97(16):e0387. doi: 10.1097/MD.0000000000010387.

DOI:10.1097/MD.0000000000010387

PMID:29668593

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5916668/

Abstract

BACKGROUND

The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia, and an increased risk of cardiovascular events. However, there are no systematic analyses, or well-conducted meta-analyses to evaluate the relationship between epicardial adipose tissue (EAT) and (MetS). The aim of this study is to examine this association of EAT with MetS in different ages and sex.

METHODS

The update systematic review, and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that firstly, examined the association between EAT and MetS, secondly, focus on cohort, case-control, and cross-sectional studies, thirdly, were conducted among in adults aged between 40 and 70 years, fourth, provided sufficient data for calculating ORs or relative risk with a 95% CI, fifth, were published as original articles written in English or other languages, and sixth, have been published until January year 2018 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators.

RESULTS

Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. This study will provide a high quality synthesis on the association of EAT and MetS.

CONCLUSION

This systematic review will provide evidence to assess whether there is a strong association of EAT and MetS, and its components.

摘要

背景

在未来几十年中，代谢综合征（MetS）及与MetS相关的中风患病率预计将急剧上升。MetS是一种复杂的疾病，包括内皮功能障碍、胰岛素抵抗、糖尿病、高血压、异位肥胖和血脂异常，以及心血管事件风险增加。然而，目前尚无系统分析或高质量的荟萃分析来评估心外膜脂肪组织（EAT）与MetS之间的关系。本研究的目的是探讨不同年龄和性别的EAT与MetS之间的这种关联。

方法

将使用从电子数据库（即PubMed、EMBASE、科学网和谷歌学术）中识别出的已发表研究进行更新的系统评价和荟萃分析。纳入的研究需满足以下条件：首先，研究EAT与MetS之间的关联；其次，聚焦队列研究、病例对照研究和横断面研究；第三，研究对象为40至70岁的成年人；第四，提供足够的数据以计算95%置信区间的比值比（OR）或相对风险；第五，以英文或其他语言发表的原创文章形式发表；第六，截至2018年1月已发表。将根据研究人员之间的讨论进行研究选择、数据收集、质量评估和统计综合分析。