代谢综合征与中风风险：更新的系统评价与荟萃分析方案
Metabolic syndrome and risk of stroke: Protocol for an update systematic review and meta-analysis.
作者信息
Roever Leonardo, Resende Elmiro Santos, Diniz Angélica Lemos Debs, Penha-Silva Nilson, O'Connell João Lucas, Gomes Paulo Fernando Silva, Zanetti Hugo Ribeiro, Roerver-Borges Anaisa Silva, Veloso Fernando César, Fidale Thiago Montes, Casella-Filho Antonio, Dourado Paulo Magno Martins, Chagas Antonio Carlos Palandri, Ali-Hasan-Al-Saegh Sadeq, Reis Paulo Eduardo Ocke, Pinto Rogério de Melo, Oliveira Gustavo B F, Avezum Álvaro, Neto Mansueto, Durães André, Silva Rose Mary Ferreira Lisboa da, Grande Antonio José, Denardi Celise, Lopes Renato Delascio, Nerlekar Nitesh, Alizadeh Shahab, Hernandez Adrian V, Biondi-Zoccai Giuseppe
机构信息
Federal University of Uberlândia, Department of Clinical Research Heart Institute (InCor), Master Institute of Education President Antonio Carlos, Department of Clinical Research, IMEPAC, Araguari, Brazil HCFMUSP-University of São Paulo Medical School, Department of Cardiology, São Paulo Faculty of Medicine ABC, Department of Cardiology Santo André, Brazil Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Department of Cardiology, Yazd, Iran Department of Specialized and General Surgery, Fluminense Federal University, Rio de Janeiro Dante Pazzanese Institute of Cardiology, São Paulo, Brazil; Dante Pazzanese Institute of Cardiology, Department of Clinical Research São Paulo Graduate Program in Medicine and Health, Department of Heath and Sciences, Federal University of Bahia Federal University of Minas Gerais, Department of Cardiology, MG Federal University of Mato Grosso, MT, Department of Medicine, Brazil FOP Unicamp, Department of Clinical Research Division of Cardiology, Duke University Medical Center, Department of Clinical Research, Durham, NC Monash Cardiovascular Research Centre and Monash Heart, Department of Cardiology, Clayton, Victoria, Australia Tehran University of Medical Sciences, Department of Medicine, Iran University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, Department of Comparative Effectiveness and Outcomes Research Health Outcomes, CT Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.
出版信息
Medicine (Baltimore). 2018 Apr;97(15):e9862. doi: 10.1097/MD.0000000000009862.
INTRODUCTION
The metabolic syndrome is composed of several cardiovascular risk factors and has a high prevalence throughout the world. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between metabolic syndrome and stroke. The aim of this study is to examine this association of metabolic syndrome with stroke in different ages and sex.
METHODS AND ANALYSIS
The update systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (i.e., PubMed, EMBASE, Web of Science, and Google Scholar. Studies that examined the association between metabolic syndrome and stroke, had a longitudinal or prospective cohort design, were conducted among in adults aged 40 to 70 years, provided sufficient data for calculating ORs or relative risk with a 95% CI, were published as original articles written in English or other languages, and have been published until December 2017 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators.
ETHICS AND DISSEMINATION
Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in stroke, and determining approaches for prevention of stroke in the future.
引言
代谢综合征由多种心血管危险因素组成，在全球范围内具有较高的患病率。然而，目前尚无系统分析或高质量的荟萃分析来评估代谢综合征与中风之间的关系。本研究旨在探讨不同年龄和性别的代谢综合征与中风之间的这种关联。
方法与分析
将使用从电子数据库（即PubMed、EMBASE、科学网和谷歌学术）中识别出的已发表研究进行更新的系统评价和荟萃分析。纳入的研究需满足以下条件：研究代谢综合征与中风之间的关联；采用纵向或前瞻性队列设计；在40至70岁的成年人中进行；提供足够的数据以计算95%置信区间的比值比（OR）或相对风险；以英文或其他语言发表的原创文章形式发表；且发表时间截至2017年12月。研究选择、数据收集、质量评估和统计综合将基于研究人员之间的讨论进行。
伦理与传播
本研究无需伦理批准，因为它基于已发表的研究。本研究的结果和发现将提交并发表在科学同行评审期刊上。本研究的发现可能有助于评估中风中的代谢综合征危险因素，并确定未来预防中风的方法。
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