心外膜脂肪组织与颈动脉疾病：系统评价和荟萃分析方案

Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis.

作者信息

Roever Leonardo, Resende Elmiro Santos, Diniz Angélica Lemos Debs, Penha-Silva Nilson, O'Connell João Lucas, Gomes Paulo Fernando Silva, Zanetti Hugo Ribeiro, Roerver-Borges Anaisa Silva, Veloso Fernando César, de Souza Fernanda Rodrigues, Duarte Poliana Rodrigues Alves, Fidale Thiago Montes, Casella-Filho Antonio, Dourado Paulo Magno Martins, Chagas Antonio Carlos Palandri, Ali-Hasan-Al-Saegh Sadeq, Reis Paulo Eduardo Ocke, Pinto Rogério de Melo Costa, Oliveira Gustavo B F, Avezum Álvaro, Neto Mansueto, Durães André, Silva Rose Mary Ferreira Lisboa da, Grande Antonio José, Denardi Celise, Lopes Renato Delascio, Nerlekar Nitesh, Alizadeh Shahab, Hernandez Adrian V, Rosa Maria Inês da, Biondi-Zoccai Giuseppe

机构信息

Federal University of Uberlândia, Department of Clinical Research.

Heart Institute (InCor), Master Institute of Education President Antonio Carlos, Department of Clinical Research, IMEPAC, Araguari.

出版信息

Medicine (Baltimore). 2018 Apr;97(17):e0273. doi: 10.1097/MD.0000000000010273.

DOI:10.1097/MD.0000000000010273

PMID:29702973

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5944522/

Abstract

BACKGROUND

Atherosclerosis is now widely recognized as a multifactorial disease with outcomes that arise from complex factors such as plaque components, blood flow, and inflammation. Epicardial adipose tissue (EAT) is a metabolically active fat depot, abundant in proinflammatory cytokines, and has been correlated with the extent and severity of carotid artery disease (CD). The locations most frequently affected by carotid atherosclerosis are the proximal internal carotid artery (ie, the origin) and the common carotid artery bifurcation. Progression of atheromatous plaque at the carotid bifurcation results in luminal narrowing, often accompanied by ulceration. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between EAT and CD. The aim of this study is to examine this association of EAT with CD in different ages and sex.

METHODS

This systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that (1) examined the association between EAT and CD, (2) focus on cohort, case-control and cross-sectional studies, (3) will conducted among in adults aged 40 to 70 years, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) will published as original articles written in English or other languages, and (6) have been published until January 2018 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators.

RESULTS

We propose the current protocol to evaluate the evaluation of EAT with ED.

CONCLUSION

This systematic review will not need ethical approval, because it does not involve human beings. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.

ETHICS AND DISSEMINATION

Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.

TRIAL REGISTRATION NUMBER

PROSPERO (CRD42018083458).

摘要

背景

动脉粥样硬化现已被广泛认为是一种多因素疾病，其结果源于斑块成分、血流和炎症等复杂因素。心外膜脂肪组织（EAT）是一个代谢活跃的脂肪库，富含促炎细胞因子，并且与颈动脉疾病（CD）的范围和严重程度相关。颈动脉粥样硬化最常受累的部位是颈内动脉近端（即起源处）和颈总动脉分叉处。颈动脉分叉处动脉粥样斑块的进展会导致管腔狭窄，常伴有溃疡形成。然而，目前尚无系统分析或高质量的荟萃分析来评估EAT与CD之间的关系。本研究的目的是探讨不同年龄和性别的EAT与CD之间的这种关联。

方法

本系统评价和荟萃分析将使用从电子数据库（即PubMed、EMBASE、科学网和谷歌学术）中识别出的已发表研究。纳入的研究需满足以下条件：（1）研究EAT与CD之间的关联；（2）聚焦队列研究、病例对照研究和横断面研究；（3）研究对象为40至70岁的成年人；（4）提供足够的数据以计算95%可信区间的比值比（OR）或相对风险；（5）以英文或其他语言发表的原创文章形式发表；（6）截至2018年1月已发表。研究选择、数据收集、质量评估和统计综合将基于研究者之间的讨论进行。