Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
PLoS One. 2018 Apr 18;13(4):e0195267. doi: 10.1371/journal.pone.0195267. eCollection 2018.
We studied associations between prenatal exposure to particulate matter with diameter ≤ 2.5 μm (PM2.5) and postpartum psychological functioning in a lower income, ethnically mixed sample of urban US women enrolled in a pregnancy cohort study. Analyses included 557 mothers who delivered at ≥37 weeks gestation. Daily estimates of residential PM2.5 over gestation were derived using a satellite-based spatio-temporally resolved model. Outcomes included the Edinburgh Postnatal Depression Scale (EPDS) score from 6 or 12 months postpartum and subscale scores for anhedonia, depressive and anxiety symptoms. Associations were also examined within racial/ethnic groups. Distributed lag models (DLMs) were implemented to identify windows of vulnerability during pregnancy.
Most mothers had less than a high school education (64%) and were primarily Hispanic (55%) and Black (29%). In the overall sample, a DLM adjusted for age, race, education, prenatal smoking, and season of delivery, we found significant associations between higher PM2.5 exposure in the second trimester and increased anhedonia subscale scores postpartum. In race stratified analyses, mid-pregnancy PM2.5 exposure was significantly associated with increased total EPDS scores as well as higher anhedonia and depressive symptom subscale scores among Black women.
Increased PM2.5 exposure in mid-pregnancy was associated with increased depressive and anhedonia symptoms, particularly in Black women.
我们研究了在美国城市中收入较低、种族混杂的孕妇队列研究中，产前暴露于直径≤2.5μm（PM2.5）颗粒物与产后心理功能之间的关系。分析纳入了 557 名妊娠≥37 周分娩的母亲。使用基于卫星的时空分辨率模型，得出了整个孕期的每日住宅 PM2.5 估计值。结果包括产后 6 或 12 个月的爱丁堡产后抑郁量表（EPDS）评分和快感缺乏、抑郁和焦虑症状的亚量表评分。还在种族/族裔群体内检查了关联。实施分布式滞后模型（DLM）以确定孕期易损性窗口。
大多数母亲的受教育程度低于高中（64%），主要是西班牙裔（55%）和黑人（29%）。在总体样本中，我们在调整了年龄、种族、教育程度、产前吸烟和分娩季节的 DLM 中发现，第二孕期 PM2.5 暴露较高与产后快感缺乏亚量表评分增加有关。在种族分层分析中，妊娠中期 PM2.5 暴露与黑人女性的总 EPDS 评分升高以及快感缺乏和抑郁症状亚量表评分升高显著相关。
妊娠中期 PM2.5 暴露增加与抑郁和快感缺乏症状增加有关，尤其是黑人女性。
