Silencing of Long Noncoding RNA Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer.

The long noncoding RNA (lncRNA) has previously been identified as a prognostic marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis of lncRNA expression profiles from RNA-Seq data and report that plays a similar role in lung cancer. Analysis of 918 lung cancer and normal lung tissues and lung cancer cell lines revealed that was significantly downregulated in lung cancer; this decreased expression was associated with poor patient survival. bound and stabilized the YBX1 protein. Silencing of triggered both cell survival and cell death signaling through dysregulation of the oncogenes YBX1, MET, and p21. In this network, p21 played an oncogenic role by promoting cell proliferation and antiapoptosis in lung cancers. played a tumor-suppressive role as indicated by inhibition of multiple cell cycle-related genes in human primary lung tumors. These data show that has potential as a new diagnostic and prognostic marker and as a therapeutic target for lung cancer. The lncRNA functions as a tumor suppressor, with potential use a diagnostic/prognostic marker and therapeutic target in lung cancer. .