• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Exosome Therapy for Stroke.

作者信息

Chen Jieli, Chopp Michael

机构信息

From the Department of Neurology, Henry Ford Hospital, Detroit, MI (J.C., M.C.)

Department of Geriatrics, Tianjin Medical University General Hospital, China (J.C.).

出版信息

Stroke. 2018 May;49(5):1083-1090. doi: 10.1161/STROKEAHA.117.018292. Epub 2018 Apr 18.

DOI:10.1161/STROKEAHA.117.018292
PMID:29669873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6028936/
Abstract
摘要

相似文献

1
Exosome Therapy for Stroke.用于中风的外泌体疗法。
Stroke. 2018 May;49(5):1083-1090. doi: 10.1161/STROKEAHA.117.018292. Epub 2018 Apr 18.
2
Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke.急性缺血性脑卒中后,静脉注射异种脂肪来源间充质干细胞(ADMSC)和ADMSC来源的外泌体可显著减少大鼠脑梗死体积并保留神经功能。
Oncotarget. 2016 Nov 15;7(46):74537-74556. doi: 10.18632/oncotarget.12902.
3
Potential of Exosomes for the Treatment of Stroke.外泌体在中风治疗中的潜力。
Cell Transplant. 2019 Jun;28(6):662-670. doi: 10.1177/0963689718816990. Epub 2018 Dec 6.
4
Cell-Based and Exosome Therapy in Diabetic Stroke.基于细胞的治疗和外泌体治疗糖尿病性中风。
Stem Cells Transl Med. 2018 Jun;7(6):451-455. doi: 10.1002/sctm.18-0014. Epub 2018 Mar 2.
5
Exosomes from hypoxic pre-treated ADSCs attenuate acute ischemic stroke-induced brain injury via delivery of circ-Rps5 and promote M2 microglia/macrophage polarization.缺氧预处理 ADSCs 来源的外泌体通过递送 circ-Rps5 减轻急性缺血性脑卒中诱导的脑损伤,并促进 M2 小胶质细胞/巨噬细胞极化。
Neurosci Lett. 2022 Jan 19;769:136389. doi: 10.1016/j.neulet.2021.136389. Epub 2021 Dec 8.
6
Role of Exosomes as a Treatment and Potential Biomarker for Stroke.外泌体在中风治疗和潜在生物标志物中的作用。
Transl Stroke Res. 2019 Jun;10(3):241-249. doi: 10.1007/s12975-018-0654-7. Epub 2018 Aug 13.
7
Pleiotropic Effects of Exosomes as a Therapy for Stroke Recovery.外泌体作为中风康复治疗的多效作用。
Int J Mol Sci. 2020 Sep 20;21(18):6894. doi: 10.3390/ijms21186894.
8
Effects of Adipose-derived Mesenchymal Stem Cell Exosomes on Corneal Stromal Fibroblast Viability and Extracellular Matrix Synthesis.脂肪间充质干细胞外泌体对角膜基质成纤维细胞活力和细胞外基质合成的影响。
Chin Med J (Engl). 2018 Mar 20;131(6):704-712. doi: 10.4103/0366-6999.226889.
9
Transplantation of adipose tissue-derived stem cell-derived exosomes ameliorates erectile function in diabetic rats.脂肪组织来源干细胞衍生外泌体移植改善糖尿病大鼠勃起功能。
Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12871. Epub 2017 Oct 23.
10
MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway.脂肪组织来源的间充质干细胞来源的 miR-199a 修饰的外泌体通过 mTOR 通路提高肝癌细胞的化疗敏感性。
J Exp Clin Cancer Res. 2020 Jan 2;39(1):4. doi: 10.1186/s13046-019-1512-5.

引用本文的文献

1
Cerebral ischemia-reperfusion injury: mechanisms and promising therapies.脑缺血再灌注损伤:机制与前景广阔的治疗方法
Front Pharmacol. 2025 Jul 16;16:1613464. doi: 10.3389/fphar.2025.1613464. eCollection 2025.
2
Enhanced Therapeutic Effects of Extracellular Vesicles Targeting MiR-137 Contribute to Functional Recovery by Attenuating Neuronal Injury After Ischemic Stroke.靶向miR-137的细胞外囊泡增强治疗效果,通过减轻缺血性中风后神经元损伤促进功能恢复。
Neurosci Bull. 2025 Jun 23. doi: 10.1007/s12264-025-01437-w.
3
Research status and future perspectives of IL‑27 in the treatment of stroke (Review).白细胞介素-27在中风治疗中的研究现状与未来展望(综述)
Int J Mol Med. 2025 Aug;56(2). doi: 10.3892/ijmm.2025.5557. Epub 2025 May 30.
4
Temperature-modulated separation of therapeutic cells, viral vectors, and exosomes using functional polymers.利用功能聚合物对治疗性细胞、病毒载体和外泌体进行温度调制分离。
Anal Sci. 2025 May 23. doi: 10.1007/s44211-025-00785-x.
5
Dual Role of Exosomes in Parkinson's Disease: Adenine Exerts a Beneficial Effect.外泌体在帕金森病中的双重作用:腺嘌呤发挥有益作用。
CNS Neurosci Ther. 2025 Apr;31(4):e70331. doi: 10.1111/cns.70331.
6
Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage.装载有miR-100-5p拮抗剂的工程化细胞外囊泡可选择性靶向损伤区域,促进脑损伤恢复。
Neurosci Bull. 2025 Apr 1. doi: 10.1007/s12264-025-01376-6.
7
The profile of inflammatory extracellular vesicles in intracerebral hemorrhage patients.脑出血患者炎症性细胞外囊泡的概况
Front Stroke. 2022;1. doi: 10.3389/fstro.2022.988081. Epub 2022 Sep 19.
8
LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.长链非编码RNA对神经炎症的调控:综述
Cell Mol Neurobiol. 2025 Mar 8;45(1):21. doi: 10.1007/s10571-025-01538-0.
9
Molecular Targeting of Ischemic Stroke: The Promise of Naïve and Engineered Extracellular Vesicles.缺血性中风的分子靶向治疗:天然和工程化细胞外囊泡的前景
Pharmaceutics. 2024 Nov 21;16(12):1492. doi: 10.3390/pharmaceutics16121492.
10
Mapping the current trends and hotspots of extracellular vesicles in Alzheimer's disease: a bibliometric analysis.绘制阿尔茨海默病细胞外囊泡的当前趋势和热点:一项文献计量分析
Front Aging Neurosci. 2024 Dec 20;16:1485750. doi: 10.3389/fnagi.2024.1485750. eCollection 2024.

本文引用的文献

1
Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer.子宫内膜癌中新型诊断和预后微小RNA特征的鉴定
Genes Cancer. 2017 May;8(5-6):566-576. doi: 10.18632/genesandcancer.144.
2
Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum.从细胞培养基和血清中分离外泌体及外泌体RNA的方法比较。
Int J Mol Med. 2017 Sep;40(3):834-844. doi: 10.3892/ijmm.2017.3080. Epub 2017 Jul 24.
3
Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma.从血浆中快速分离和检测外泌体及相关生物标志物。
ACS Nano. 2017 Jul 25;11(7):6641-6651. doi: 10.1021/acsnano.7b00549. Epub 2017 Jul 3.
4
Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage.外泌体促进实验性脑出血动物模型后的恢复。
J Cereb Blood Flow Metab. 2018 May;38(5):767-779. doi: 10.1177/0271678X17708917. Epub 2017 May 19.
5
Plasma MicroRNA Levels Following Resection of Metastatic Melanoma.转移性黑色素瘤切除术后的血浆微小RNA水平
Bioinform Biol Insights. 2017 Feb 23;11:1177932217694837. doi: 10.1177/1177932217694837. eCollection 2017.
6
Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro.体外血脑屏障模型中外泌体迁移的阐释
Cell Mol Bioeng. 2016 Dec;9(4):509-529. doi: 10.1007/s12195-016-0458-3. Epub 2016 Jul 7.
7
The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.外泌体在中枢神经系统炎症中的作用及其与多发性硬化症的关联。
J Neuroimmunol. 2017 May 15;306:1-10. doi: 10.1016/j.jneuroim.2017.02.002. Epub 2017 Feb 6.
8
Plasma miR-145, miR-20a, miR-21 and miR-223 as novel biomarkers for screening early-stage non-small cell lung cancer.血浆miR-145、miR-20a、miR-21和miR-223作为筛查早期非小细胞肺癌的新型生物标志物。
Oncol Lett. 2017 Feb;13(2):669-676. doi: 10.3892/ol.2016.5462. Epub 2016 Dec 6.
9
Exosomes and their role in the micro-/macro-environment: a comprehensive review.外泌体及其在微/宏观环境中的作用:综述
J Biomed Res. 2017 Sep 26;31(5):386-394. doi: 10.7555/JBR.30.20150162.
10
Emerging potential of exosomes for treatment of traumatic brain injury.外泌体治疗创伤性脑损伤的新潜力。
Neural Regen Res. 2017 Jan;12(1):19-22. doi: 10.4103/1673-5374.198966.