School of Psychology, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Department of Psychology, University of California, Los Angeles, Los Angeles, California, United States of America.
Sci Rep. 2018 Apr 18;8(1):6190. doi: 10.1038/s41598-018-24549-y.
Autobiographical remembering can depend on two forms of memory: episodic (event) memory and autobiographical semantic memory (remembering personally relevant semantic knowledge, independent of recalling a specific experience). There is debate about the degree to which the neural signals that support episodic recollection relate to or build upon autobiographical semantic remembering. Pooling data from two fMRI studies of memory for real-world personal events, we investigated whether medial temporal lobe (MTL) and parietal subregions contribute to autobiographical episodic and semantic remembering. During scanning, participants made memory judgments about photograph sequences depicting past events from their life or from others' lives, and indicated whether memory was based on episodic or semantic knowledge. Results revealed several distinct functional patterns: activity in most MTL subregions was selectively associated with autobiographical episodic memory; the hippocampal tail, superior parietal lobule, and intraparietal sulcus were similarly engaged when memory was based on retrieval of an autobiographical episode or autobiographical semantic knowledge; and angular gyrus demonstrated a graded pattern, with activity declining from autobiographical recollection to autobiographical semantic remembering to correct rejections of novel events. Collectively, our data offer insights into MTL and parietal cortex functional organization, and elucidate circuitry that supports different forms of real-world autobiographical memory.
情景（事件）记忆和自传体语义记忆（记住与个人相关的语义知识，不依赖于回忆特定的经历）。关于支持情景回忆的神经信号在何种程度上与自传体语义记忆有关或建立在自传体语义记忆之上，存在争议。我们从两项关于真实个人事件记忆的 fMRI 研究中汇集数据，研究内侧颞叶（MTL）和顶叶亚区是否有助于自传体情景和语义记忆。在扫描过程中，参与者对描述自己或他人生活中过去事件的照片序列进行记忆判断，并指出记忆是基于情景知识还是语义知识。结果揭示了几种不同的功能模式：大多数 MTL 亚区的活动与自传体情景记忆选择性相关；当记忆基于自传体情节或自传体语义知识的检索时，海马尾部、顶叶上回和顶内沟同样被激活；角回表现出一种渐变模式，其活动从自传体回忆下降到自传体语义回忆，再到对新事件的正确拒绝。总的来说，我们的数据提供了对 MTL 和顶叶皮层功能组织的深入了解，并阐明了支持不同形式真实自传体记忆的电路。
