Department of EEG Source Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, P. R. China.
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China.
Sci Rep. 2018 Apr 18;8(1):6230. doi: 10.1038/s41598-018-24547-0.
Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy. TCM was observed to have beneficial effects on aspects of the Positive and Negative Syndrome Scale (PANSS) including total score changes and negative score changes, as well as clinical effects estimated with PANSS or the Brief Psychiatric Rating Scale (BPRS). The changes in extrapyramidal side effects (RSESE) scores from baseline to the end of the treatment period were similar in two groups of related trials. TCM was also reported to mitigate some anti-psychotic related side-effects and overall, TCM adjuvant therapy was generally safe and well tolerated. While, the results indicated the potential utility of TCM as an alternative adjunctive therapeutic for refractory schizophrenia treatment, there remains a need for further high-quality studies.
虽然最近的研究集中在中药（TCM）治疗难治性精神分裂症上，报告称它可能是有益的，但仍然缺乏令人信服的证据和关键的荟萃分析工作，以证明其作为辅助治疗的有效性。因此，我们进行了一项荟萃分析，以调查 TCM 联合抗精神病药物治疗难治性精神分裂症的疗效。纳入了截至 2016 年 12 月发表的 14 篇文章，共涉及 1725 名患者，这些文章比较了抗精神病药物治疗与 TCM 单独治疗或 TCM 作为辅助治疗的效果。结果表明，TCM 对阳性和阴性症状量表（PANSS）的总分变化和阴性症状评分变化等方面有有益的影响，以及用 PANSS 或简明精神病评定量表（BPRS）估计的临床效果。在相关试验的两组中，从基线到治疗期末的锥体外系副作用（RSESE）评分的变化相似。TCM 还被报道可以减轻一些抗精神病相关的副作用，总的来说，TCM 辅助治疗通常是安全和耐受良好的。虽然结果表明 TCM 作为难治性精神分裂症治疗的替代辅助治疗具有潜在的应用价值，但仍需要进一步的高质量研究。
