Shi Xiao-Jie, Fan Fang-Cheng, Liu Hua, Ai Yang-Wen, Liu Qing-Shan, Jiao Yu-Guo, Cheng Yong
Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.
College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Front Pharmacol. 2021 Jan 20;11:616088. doi: 10.3389/fphar.2020.616088. eCollection 2020.
Despite several studies suggesting the effectiveness of traditional Chinese medicine (TCM) in schizophrenia, there is still a lack of systematic summary and analysis on the role of TCM as adjuvant therapy in chronic schizophrenia. For this purpose, we conducted a meta-analysis to study the efficacy of TCM as an adjuvant combined with antipsychotics in the treatment of chronic schizophrenia. Until April 2020, based on the review of six electronic databases, eight articles were selected. The articles compared TCM decoction assisted antipsychotic therapies with an antipsychotic alone in the treatment of chronic schizophrenia by analyzing a total of 810 cases. The results showed that TCM combined with antipsychotics have beneficial effects on the Positive and Negative Syndrome Scale (PANSS), including the changes in total score, negative score, and the clinical effects evaluated by the PANSS scale. Subgroup analysis showed that the effects of auxiliary TCM with different efficacy on the positive and psychopathological scores were significantly different. It was found that adjuvant treatment with TCM can reduce some side effects and improve the patient's living conditions in the evaluation of the Schizophrenia Quality Of Life Scale (SQLS). Many studies have proved that TCM is safe and well-tolerated. Although the difficulties of using limited TCM remains to be generalized, it still has great potential in the adjuvant treatment of chronic schizophrenia.
尽管多项研究表明中药在精神分裂症治疗中具有有效性，但对于中药在慢性精神分裂症辅助治疗中的作用仍缺乏系统的总结与分析。为此，我们进行了一项荟萃分析，以研究中药联合抗精神病药物辅助治疗慢性精神分裂症的疗效。截至2020年4月，通过检索六个电子数据库，筛选出八篇文章。这些文章通过分析总共810例病例，比较了中药汤剂辅助抗精神病药物治疗与单纯使用抗精神病药物治疗慢性精神分裂症的效果。结果表明，中药联合抗精神病药物对阳性与阴性症状量表（PANSS）有有益影响，包括总分、阴性得分的变化以及通过PANSS量表评估的临床疗效。亚组分析显示，不同功效的辅助中药对阳性和精神病理得分的影响存在显著差异。在精神分裂症生活质量量表（SQLS）评估中发现，中药辅助治疗可减少一些副作用并改善患者的生活状况。许多研究已证明中药安全且耐受性良好。尽管使用有限的中药存在的困难仍有待归纳，但它在慢性精神分裂症的辅助治疗中仍具有巨大潜力。
