Fallah Zahra, Feizi Awat, Hashemipour Mahin, Kelishadi Roya
Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mater Sociomed. 2018 Mar;30(1):20-25. doi: 10.5455/msm.2018.30.20-25.
Metabolic syndrome (MetS) has several health consequences. Liver enzymes elevation is among them.
This study aimed to assess the effects of fermented Camel milk (FCM), as a functional food and dairy, on some features of MetS in adolescents including liver enzymes status, serum lipids and anthropometric measures.
Overweight/obese adolescents with MetS were randomly assigned to FCM 250 cc per day for 8 weeks, a 4-week washout, and then to diluted Cow's yogurt (DCY) 250 cc per day for 8 weeks, or the reverse sequence. Anthropometric measures, liver enzymes and serum lipids were measured just before and after each one of the four periods. A three-day food record and physical activity questionnaire were completed before each period. Statistical analyses were done using Minitab and SPSS soft-wares considering the significance level of 0.05.
Twenty-four participants with a mean age (SD) of 13.77 (1.87) years (range: 10.45-16.25) (58% girls) completed the study. It resulted significant mean reduction of aspartate aminotransferase (AST) (-3.75 U/L [95% CI: -7.06; -0.43]; p=0.042) and alanine aminotransferase (ALT) (-2.54 U/L [95% CI: -3.33; -2.24], and p=0.006) and AST/ALT ratio (-0.16 U/L [95% CI: -0.28; -0.05]; p= 0.029) by FCM consumption in comparison to DCY. Non-significant favorable effects on anthropometric measures and serum lipids were seen as well.
According to the observed favorable effects of fermented camel milk on liver enzymes, its consumption may be considered as a functional food supplement in related circumstances.
代谢综合征（MetS）会引发多种健康问题，肝酶升高便是其中之一。
本研究旨在评估发酵骆驼奶（FCM）这种功能性食品和乳制品对青少年代谢综合征某些特征的影响，包括肝酶状况、血脂和人体测量指标。
患有代谢综合征的超重/肥胖青少年被随机分为两组，一组每天饮用250毫升发酵骆驼奶，持续8周，之后有4周的洗脱期，然后每天饮用250毫升稀释的酸奶（DCY），持续8周；另一组顺序相反。在四个阶段中的每个阶段前后分别测量人体测量指标、肝酶和血脂。在每个阶段之前完成一份为期三天的饮食记录和身体活动问卷。使用Minitab和SPSS软件进行统计分析，显著性水平设定为0.05。
24名平均年龄（标准差）为13.77（1.87）岁（范围：10.45 - 16.25岁）（58%为女孩）的参与者完成了研究。与饮用稀释酸奶相比，饮用发酵骆驼奶导致天冬氨酸转氨酶（AST）显著平均降低（-3.75 U/L [95%置信区间：-7.06；-0.43]；p = 0.042）、丙氨酸转氨酶（ALT）显著平均降低（-2.54 U/L [95%置信区间：-3.33；-2.24]，p = 0.006）以及AST/ALT比值显著平均降低（-0.16 U/L [95%置信区间：-0.28；-0.05]；p = 0.029）。在人体测量指标和血脂方面也观察到了非显著的有益影响。
根据观察到的发酵骆驼奶对肝酶的有益影响，在相关情况下，饮用发酵骆驼奶可被视为一种功能性食品补充剂。
