Fallah Zahra, Feizi Awat, Hashemipour Mahin, Kelishadi Roya
Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2018 Apr 26;23:32. doi: 10.4103/jrms.JRMS_1191_17. eCollection 2018.
This study, for the first time, aimed to assess the effects of fermented camel milk (FCM) on glycemic and inflammatory parameters related to metabolic syndrome (MetS), an aggregation of cardiometabolic risk factors, in adolescents.
In a double-blind, randomized crossover trial, overweight/obese adolescents (fulfilling MetS criteria, aged 11-18 years) were randomly assigned to receive FCM 250 cc per day for an 8-week period, a 4-week washout, and then diluted cow's yogurt (DCY) 250 cc/day for another 8-week period, or the reverse sequence. Fasting blood sugar (FBS), fasting insulin, insulin resistance by three equations, incretin hormone glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP1) as well as inflammatory markers such as interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-α) were measured before and after each of the four periods. A 3-day food record and physical activity questionnaire were completed before each period. Statistical analyses were done using Minitab and SPSS software considering the significance level of 0.05.
Twenty-four participants with a mean (standard deviation) age of 13.77 (1.87) years (range: 10.45-16.25 years) (58% girls) completed the study. It resulted in nonsignificant mean reduction in IL6 (-18.28 pg/mL [95% confidence interval [CI]: -47.48; 10.90]; = 0.20) and nonsignificant increase in glucose metabolizing hormones such as GIP (683.10 pg/mL [95% CI: -457.84; 1824.0]; = 0.22) and GLP1 (6.98 pg/mL [95% CI: -66.61; 80.57]; = 0.84) by FCM consumption in comparison to DCY. Nonsignificant decrease was observed in TNF-α in the first periods of the study. The changes of FBS, fasting insulin, and insulin resistance indices were not statistically significant as well.
According to preliminary positive influences of FCM on inflammatory markers, and findings related to glucose metabolism, we suggest conducting further studies on its clinical impacts.
本研究首次旨在评估发酵骆驼奶（FCM）对青少年与代谢综合征（MetS）相关的血糖和炎症参数的影响，代谢综合征是心血管代谢危险因素的聚集。
在一项双盲、随机交叉试验中，超重/肥胖青少年（符合MetS标准，年龄11 - 18岁）被随机分配，先接受每天250毫升FCM，为期8周，然后有4周的洗脱期，接着再接受每天250毫升的稀释酸奶（DCY），为期8周，或者采用相反的顺序。在四个阶段的每个阶段前后，测量空腹血糖（FBS）、空腹胰岛素、通过三个公式计算的胰岛素抵抗、肠促胰岛素激素葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽 - 1（GLP1），以及炎症标志物如白细胞介素6（IL6）和肿瘤坏死因子 - α（TNF - α）。在每个阶段之前完成一份3天的食物记录和身体活动问卷。使用Minitab和SPSS软件进行统计分析，显著性水平设定为0.05。
24名参与者完成了研究，其平均（标准差）年龄为13.77（1.87）岁（范围：10.45 - 16.25岁）（58%为女孩）。与DCY相比，食用FCM导致IL6平均降低但无统计学意义（-18.28 pg/mL [95%置信区间[CI]：-47.48；10.90]；P = 0.20），以及葡萄糖代谢激素如GIP（683.10 pg/mL [95%CI：-457.84；1824.0]；P = 0.22）和GLP1（6.98 pg/mL [95%CI：-66.61；80.57]；P = 0.84）无显著升高。在研究的第一阶段观察到TNF - α有不显著的下降。FBS、空腹胰岛素和胰岛素抵抗指数的变化也无统计学意义。
根据FCM对炎症标志物的初步积极影响以及与葡萄糖代谢相关的研究结果，我们建议对其临床影响进行进一步研究。
