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三文鱼和银鱼头磷脂提取物对 C57BL/6J 小鼠高脂饮食诱导代谢综合征的比较研究。

Comparison of the Effect of Phospholipid Extracts from Salmon and Silver Carp Heads on High-Fat-Diet-Induced Metabolic Syndrome in C57BL/6J Mice.

机构信息

School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education (Wuhan Polytechnic University), Wuhan 430023, China.

出版信息

Mar Drugs. 2023 Jul 19;21(7):409. doi: 10.3390/md21070409.

DOI:10.3390/md21070409
PMID:37504940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10381321/
Abstract

Metabolic syndrome (MetS) is a global health problem, and EPA/DHA-enriched phospholipids (EPA/DHA-PLs) have been found to have positive effects on MetS improvement. Currently, research on EPA/DHA-PL mainly focuses on special and rare seafood, such as phospholipids derived from krill, sea cucumber, squid, and fish roe. However, it has been recently demonstrated that abundant EPA/DHA-PL can also be found in bulk fish and its by-products. Nonetheless, there is still limited research on the biological activities of EPA/DHA-PL derived from these sources. The aim of this study was to investigate the effect of phospholipid extracts from the heads of salmon and silver carp (S-PLE and SC-PLE) on the high-fat-diet-induced MetS in C57/BL mice. After an 8-week intervention, both SC-PLE and S-PLE had a significant ameliorating effect on MetS. Moreover, SC-PLE was more effective than S-PLE in reducing liver inflammation and fasting glucose. Both of the PL extracts were able to regulate the expression of key genes in lipid synthesis, fatty acid β-oxidation, and insulin signaling pathways. Compared with S-PLE, dietary SC-PLE had a greater influence on liver metabolomics. Pathway enrichment analysis showed that the differential metabolites of SC-PLE were mainly involved in arachidonic acid metabolism and glutathione metabolism. The results indicated that the different metabolic regulation methods of S-PLE and SC-PLE could be related to their variant molecular composition in EPA/DHA-PL.

摘要

代谢综合征（MetS）是一个全球性的健康问题，已发现富含 EPA/DHA 的磷脂（EPA/DHA-PL）对改善 MetS 具有积极作用。目前，EPA/DHA-PL 的研究主要集中在特殊和稀有的海鲜上，如磷虾、海参、鱿鱼和鱼卵中提取的磷脂。然而，最近已经证明大量的 EPA/DHA-PL 也可以在大宗鱼类及其副产品中找到。尽管如此，对于这些来源的 EPA/DHA-PL 的生物学活性的研究仍然有限。本研究旨在探讨来自三文鱼和白鲢鱼头的磷脂提取物（S-PLE 和 SC-PLE）对高脂肪饮食诱导的 C57/BL 小鼠 MetS 的影响。经过 8 周的干预，SC-PLE 和 S-PLE 均对 MetS 有显著的改善作用。此外，SC-PLE 在降低肝脏炎症和空腹血糖方面比 S-PLE 更有效。两种 PL 提取物都能够调节脂质合成、脂肪酸β-氧化和胰岛素信号通路中的关键基因表达。与 S-PLE 相比，饮食中的 SC-PLE 对肝脏代谢组学有更大的影响。通路富集分析表明，SC-PLE 的差异代谢物主要涉及花生四烯酸代谢和谷胱甘肽代谢。结果表明，S-PLE 和 SC-PLE 的不同代谢调节方式可能与其 EPA/DHA-PL 分子组成的差异有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/4893879e0929/marinedrugs-21-00409-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/bbe5bf017de3/marinedrugs-21-00409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/ebee0a2e1959/marinedrugs-21-00409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/e85bd3e9f861/marinedrugs-21-00409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/750fc672242a/marinedrugs-21-00409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/482071976002/marinedrugs-21-00409-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/bd33f95cb179/marinedrugs-21-00409-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/05b67c3803f0/marinedrugs-21-00409-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/84ec1fa48717/marinedrugs-21-00409-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/4893879e0929/marinedrugs-21-00409-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/bbe5bf017de3/marinedrugs-21-00409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/ebee0a2e1959/marinedrugs-21-00409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/e85bd3e9f861/marinedrugs-21-00409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/750fc672242a/marinedrugs-21-00409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/482071976002/marinedrugs-21-00409-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/bd33f95cb179/marinedrugs-21-00409-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/05b67c3803f0/marinedrugs-21-00409-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/84ec1fa48717/marinedrugs-21-00409-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e495/10381321/4893879e0929/marinedrugs-21-00409-g009.jpg

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