Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Oxid Med Cell Longev. 2018 Jan 29;2018:9304091. doi: 10.1155/2018/9304091. eCollection 2018.
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.
代谢重编程是癌症的标志之一。Nrf2 通路是参与细胞防御和对抗氧化应激的关键信号级联反应之一。Nrf2 在癌症代谢中的重要性开始被认识到。在这篇小综述中，我们重点介绍了 Nrf2 介导的癌症代谢重编程，并旨在强调 Nrf2 在调节恶性转化、癌症增殖以及通过代谢适应发展治疗耐药性方面的作用。我们希望在不久的将来，能够基于 Nrf2 指导的癌症代谢重编程，开发出用于癌症的非侵入性生物标志物和新型治疗方法。
