Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Bionanomaterials & Translational Engineering Laboratory, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing, 100190, China.
Adv Mater. 2018 Jun;30(23):e1800180. doi: 10.1002/adma.201800180. Epub 2018 Apr 19.
Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal-organic-framework (MOF)-derived carbon nanostructure that contains porphyrin-like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle-assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high-speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure-dependent SDT enhancement of a MOF-derived carbon nanostructure.
声动力学疗法（SDT）可以克服光触发治疗方式的深度渗透障碍这一关键问题。然而，发现具有高声敏化效率和良好稳定性的声敏剂仍然是一个重大挑战。在这项研究中，确定了一种含有卟啉样金属中心（PMCS）的金属有机骨架（MOF）衍生碳纳米结构作为一种优异的声敏剂的巨大潜力。令人兴奋的是，与无定形碳纳米球相比，PMCS 的优越声敏化效果被认为与其在 MOF 衍生纳米结构中的卟啉大环密切相关，因为其具有较大的最高占据分子轨道（HOMO）-最低未占据分子轨道（LUMO）间隙，从而产生更多的活性氧（ROS）。纳米颗粒辅助空化过程，包括空化泡和微射流的可视化形成，也首次通过高速摄像机捕获。通过电子顺磁共振和染料测量验证了 PMCS 在超声下产生的高 ROS，随后进行了细胞破坏和高肿瘤抑制效率（85%）。从理解 MOF 衍生碳纳米结构的结构依赖性 SDT 增强的角度来看，这一知识非常重要。
