State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.
University of Science and Technology of China, Hefei 230026, P. R. China.
Bioconjug Chem. 2021 Apr 21;32(4):661-666. doi: 10.1021/acs.bioconjchem.1c00039. Epub 2021 Mar 12.
Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable of generating large amounts of reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO NPs) were successfully synthesized by using COF as a template. Under ultrasound (US) irradiation, large quantities of ROS can be generated, and compared with pure TiO NPs, the SDT performance of COF-TiO nanoparticles was significantly improved due to the narrower band gap. Both in vitro and in vivo experiments demonstrated the great tumor inhibitory effect via COF-TiO-mediated SDT. This work broadens the biomedical applications of COF-based composites.
声动力学疗法（SDT）因其具有较高的组织穿透深度而受到广泛关注。然而，开发能够产生大量活性氧（ROS）的新型声敏剂仍然是一个挑战。在此，通过使用 COF 作为模板，成功合成了共价有机骨架-氧化钛纳米粒子（COF-TiO NPs）。在超声（US）照射下，可产生大量 ROS，与纯 TiO NPs 相比，由于较窄的带隙，COF-TiO 纳米粒子的 SDT 性能得到显著提高。体外和体内实验均表明，通过 COF-TiO 介导的 SDT 具有很强的肿瘤抑制作用。这项工作拓宽了基于 COF 的复合材料的生物医学应用。
