用于酚类的-Boc保护和芳基化的氧化铁-钴纳米催化剂

Iron Oxide-Cobalt Nanocatalyst for --Boc Protection and Arylation of Phenols.

作者信息

Gade Vilas B, Goswami Anandarup, Varma Rajender S, Shelke Sharad N, Gawande Manoj B

机构信息

P. G. & Research Center, Department of Chemistry, S. S. G. M. College, Kopargaon, Dist., Ahmednagar 423601, India.

Division of Chemistry, Department of Sciences and Humanities, Vignan's Foundation for Science, Technology and Research Vadlamudi, Guntur 522213, India.

出版信息

Nanomaterials (Basel). 2018 Apr 17;8(4):246. doi: 10.3390/nano8040246.

Efficient and general protocols for the --boc protection and -arylation of phenols were developed in this paper using a recyclable magnetic Fe₃O₄-Co₃O₄ nanocatalyst (Nano-Fe-Co), which is easily accessible via simple wet impregnation techniques in aqueous mediums from inexpensive precursors. The results showed the catalysts were well characterized by XRD (X-ray Diffraction), ICP-AES (Inductive Coupled Plasma Atomic Emission Spectroscopy), TEM (Transmission Electron Microscopy), TOF-SIMS (Time-Of-Flight Secondary Ion Mass Spectrometry) and XPS (X-ray Photoelectron Spectroscopy). The --boc protection and -arylation of phenols was accomplished in good to excellent yields (85–95%) and the catalyst was reusable and recyclable with no loss of catalytic activity for at least six repetitions.

本文利用可循环使用的磁性Fe₃O₄-Co₃O₄纳米催化剂（纳米铁-钴）开发了高效通用的酚类的叔丁氧羰基（Boc）保护和芳基化反应方案，该催化剂可通过简单的湿浸渍技术在水性介质中由廉价前驱体制备得到。结果表明，通过X射线衍射（XRD）、电感耦合等离子体原子发射光谱（ICP-AES）、透射电子显微镜（TEM）、飞行时间二次离子质谱（TOF-SIMS）和X射线光电子能谱（XPS）对催化剂进行了很好的表征。酚类的叔丁氧羰基保护和芳基化反应产率良好至优异（85%-95%），且该催化剂可重复使用和循环利用，至少重复六次催化活性无损失。