Division of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Division of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Clin Neurophysiol. 2018 Jul;129(7):1458-1466. doi: 10.1016/j.clinph.2018.03.010. Epub 2018 Apr 3.
We aim to establish that interictal fast ripples (FR; 250-500 Hz) are detectable on scalp EEG, and to investigate their association to epilepsy.
Scalp EEG recordings of a subset of children with tuberous sclerosis complex (TSC)-associated epilepsy from two large multicenter observational TSC studies were analyzed and compared to control children without epilepsy or any other brain-based diagnoses. FR were identified both by human visual review and compared with semi-automated review utilizing a deep learning-based FR detector.
Seven out of 7 children with TSC-associated epilepsy had scalp FR compared to 0 out of 4 children in the control group (p = 0.003). The automatic detector has a sensitivity of 98% and false positive rate with average of 11.2 false positives per minute.
Non-invasive detection of interictal scalp FR was feasible, by both visual and semi-automatic detection. Interictal scalp FR occurred exclusively in children with TSC-associated epilepsy and were absent in controls without epilepsy. The proposed detector achieves high sensitivity of FR detection; however, expert review of the results to reduce false positives is advised.
Interictal FR are detectable on scalp EEG and may potentially serve as a biomarker of epilepsy in children with TSC.
我们旨在确定头皮脑电图上可检测到发作间期快涟漪（FR；250-500 Hz），并研究其与癫痫的关联。
对来自两项大型多中心观察性结节性硬化症相关癫痫研究的一组结节性硬化症相关癫痫儿童的头皮脑电图记录进行分析，并与无癫痫或任何其他基于大脑的诊断的对照组儿童进行比较。FR 通过人工视觉审查和利用基于深度学习的 FR 检测器的半自动审查进行识别。
7 名患有结节性硬化症相关癫痫的儿童中有 7 名出现头皮 FR，而对照组中 4 名儿童中没有出现（p=0.003）。自动检测器的灵敏度为 98%，平均每分钟假阳性率为 11.2 个。
通过视觉和半自动检测，非侵入性检测发作间期头皮 FR 是可行的。发作间期头皮 FR 仅发生在患有结节性硬化症相关癫痫的儿童中，而在无癫痫的对照组中不存在。所提出的检测器实现了 FR 检测的高灵敏度；然而，建议对结果进行专家审查以减少假阳性。
发作间期 FR 可在头皮脑电图上检测到，可能是结节性硬化症儿童癫痫的潜在生物标志物。
