Warnakulasuriya Saman
Emeritus Professor, King's College London, UK; WHO Collaborating Centre for Oral Cancer, London, UK.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):582-590. doi: 10.1016/j.oooo.2018.03.011. Epub 2018 Apr 4.
Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Several variants of leukoplakia are recognized, and clinical subtyping may help determine the prognosis to a limited extent. Biopsy is essential to confirm the provisional clinical diagnosis, and timely referral to a specialist is indicated. Certain OPMDs, such as oral submucous fibrosis, are encountered particularly in population groups from Asia with specific lifestyle habits. This review provides clinical descriptions of the wide range of potentially malignant disorders encountered in the oral cavity as a prelude to the topics discussed in this focus issue.
口腔潜在恶性疾病（OPMDs）是口腔浸润性癌发病前的状态。该术语涵盖了世界卫生组织（WHO）早期定义中提到的癌前病变和状态。白斑是最常见的OPMD；红斑虽然罕见，但更为严重。白斑有几种变体，临床分型在一定程度上有助于判断预后。活检对于确诊初步临床诊断至关重要，且建议及时转诊至专科医生处。某些OPMDs，如口腔黏膜下纤维化，在具有特定生活习惯的亚洲人群中尤为常见。本综述提供了口腔中遇到的各种潜在恶性疾病的临床描述，作为本期重点议题所讨论主题的前奏。
