Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Osaka, Japan.
Environmental Health Division, Health and Medical Care Office, Department of Health and Public Welfare, Nagoya, Aichi, Japan.
Infect Genet Evol. 2018 Aug;62:122-129. doi: 10.1016/j.meegid.2018.04.013. Epub 2018 Apr 17.
Mycobacterium avium subspecies hominissuis (MAH) is an important cause of infection in human pulmonary and swine intestinal cases. Although MAH is isolated from environmental sources frequently, infections of other animals have rarely been analysed. Recently, we detected granulomatous inflammation in bovine lung as an abnormal postmortem inspection case. To ascertain its genetic profile, we conducted a variable numbers of tandem repeats (VNTR) analysis and genomic characterization using deep sequencing. The VNTR type was a unique profile that differed from reported genotypes, but it was assigned within a broad genotypic complex of isolates from human patients and bathrooms. Genomic comparison with 116 registered genome sequences of the subspecies revealed that the strain was separate from five major genetic population groups proposed previously. Although the infection source remains unclear, its isolation from various resources such as animal infection cases should be elucidated more extensively to reveal its genetic diversity and ecological context.
鸟分枝杆菌亚种 Homo sapiens（MAH）是人类肺部和猪肠道感染的重要病原体。虽然 MAH 经常从环境源中分离出来，但其他动物的感染很少被分析。最近，我们在牛肺中检测到肉芽肿性炎症，这是一种异常的剖检病例。为了确定其遗传特征，我们使用深度测序进行了可变数量串联重复（VNTR）分析和基因组特征分析。VNTR 类型是一种独特的谱，与报道的基因型不同，但它属于从人类患者和浴室中分离出来的广泛基因型复合体。与该亚种的 116 个已注册基因组序列进行基因组比较表明，该菌株与先前提出的五个主要遗传种群组不同。虽然感染源尚不清楚，但应更广泛地阐明其从动物感染病例等各种资源中的分离，以揭示其遗传多样性和生态背景。
