Bastide Amandine, David Alexandre
IGF, CNRS, INSERM, Univ. Montpellier, F-34094, Montpellier, France.
Oncogenesis. 2018 Apr 20;7(4):34. doi: 10.1038/s41389-018-0044-8.
The ribosome has long been considered as a consistent molecular factory, with a rather passive role in the translation process. Recent findings have shifted this obsolete view, revealing a remarkably complex and multifaceted machinery whose role is to orchestrate spatiotemporal control of gene expression. Ribosome specialization discovery has raised the interesting possibility of the existence of its malignant counterpart, an 'oncogenic' ribosome, which may promote tumor progression. Here we weigh the arguments supporting the existence of an 'oncogenic' ribosome and evaluate its role in cancer evolution. In particular, we provide an analysis and perspective on how the ribosome may play a critical role in the acquisition and maintenance of cancer stem cell phenotype.
长期以来，核糖体一直被视为一个稳定的分子工厂，在翻译过程中扮演相当被动的角色。最近的研究结果改变了这一过时的观点，揭示了一种极其复杂且多面的机制，其作用是协调基因表达的时空控制。核糖体特化的发现引发了一个有趣的可能性，即存在其恶性对应物——“致癌”核糖体，它可能促进肿瘤进展。在此，我们权衡支持“致癌”核糖体存在的论据，并评估其在癌症演变中的作用。特别是，我们对核糖体如何在癌症干细胞表型的获得和维持中发挥关键作用进行了分析并提出了观点。
