Singh Gurinder
Clinical Professor of Ophthalmology, The University of Kansas Medical Center, Kansas City, Kansas, USA.
The University of Missouri-Kansas City Medical Center, Kansas City, Missouri, USA.
Ann Transl Med. 2023 Mar 31;11(6):266. doi: 10.21037/atm-22-3506. Epub 2023 Feb 22.
Conjunctival papilloma commonly develops in infants and children. It is believed that the etiologic agent, human papillomavirus (HPV), gets implanted from the infected maternal birth canal in the conjunctival sac of the new borne while parturition. It grows as solitary or multiple pedunculated benign masses adjacent to the caruncle. It is uncommon but if growing in adults it grows on the limbal conjunctiva and could be malignant.
An Afro-American adult male developed two distinct conjunctival growths on his left lower lid. One growth was pedunculated and the second one sessile. The initial diagnosis of 'benign conjunctival papillomas' was made. Patient was recommended to wait and watch. After about two years the neoplasia had doubled their sizes. Surgical excisional biopsy was performed for diagnostic and therapeutic reasons. The tumor beds were treated with intra-operative cryotherapy using liquid nitrogen and applying double-freeze-thaw technique. Histopathology proved the masses to be benign and caused by HPV. Recurrence and seeding of virus during surgical excision leading to multiple new masses are dreaded complications during management of conjunctival papilloma. Though a short follow-up, yet after three months there were no signs of recurrence.
A brief review of literature is presented to highlight the fact that rarely such conjunctival papillomas may develop at unusual sites and in adults. We believe that the uncommon demographic and anatomic presentation of this case is worth sharing with ophthalmic community.
结膜乳头状瘤常见于婴幼儿。据信,病因是人乳头瘤病毒(HPV),在分娩时从受感染的母体产道植入新生儿的结膜囊中。它生长为与泪阜相邻的单个或多个有蒂的良性肿物。这种情况并不常见,但如果在成人中生长,它会生长在角膜缘结膜上,并且可能是恶性的。
一名非裔美国成年男性左下眼睑出现两个明显的结膜肿物。一个肿物有蒂,另一个无蒂。初步诊断为“良性结膜乳头状瘤”。建议患者等待观察。大约两年后,肿瘤大小翻倍。出于诊断和治疗目的进行了手术切除活检。术中使用液氮并应用双冻融技术对肿瘤床进行冷冻治疗。组织病理学证明肿物为良性,由HPV引起。手术切除期间病毒复发和播散导致多个新肿物是结膜乳头状瘤治疗过程中令人担忧的并发症。虽然随访时间短,但三个月后没有复发迹象。
简要回顾文献以强调这样一个事实,即结膜乳头状瘤很少会在不寻常的部位和成人中发生。我们认为该病例不常见的人口统计学和解剖学表现值得与眼科界分享。