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L. 叶提取物可减轻急性肺损伤小鼠的肺部炎症。

L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury.

机构信息

Programa de Pós-Graduação, Universidade CEUMA, São Luís, MA, Brazil.

Programa de Pós-Graduação da Rede BIONORTE, Universidade Federal do Amazônas, Manaus, AM, Brazil.

出版信息

J Immunol Res. 2018 Feb 20;2018:6879183. doi: 10.1155/2018/6879183. eCollection 2018.

DOI:10.1155/2018/6879183
PMID:29675437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5838491/
Abstract

The hydroalcoholic extract of (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Swiss mice received either EAFPg at different doses or dexamethasone (per os) prior to LPS intranasal instillation. Vehicle-treated mice were used as controls. Animals were culled at 4 h after LPS challenge, and the bronchoalveolar lavage fluid (BALF) and lung samples were collected for analysis. EAFPg and kaempferol effects on NO and cytokine production by LPS-stimulated RAW 264.7 macrophages were also investigated. Pretreatment with EAFPg (100-300 mg/kg) markedly reduced cell accumulation (specially neutrophils) and collagen deposition in the lungs of ALI mice. The same animals presented with reduced lung and BALF TNF- and IL-1 expression in comparison with vehicle controls ( < 0.05). Additionally, incubation with either EAFPg or kaempferol (100 g/ml) reduced NO production and cytokine gene expression in cultured LPS-treated RAW 264.7 macrophages. Overall, these results demonstrate that the prophylactic treatment with EAFPg attenuates acute lung inflammation. We suggest this fraction may be useful in treating ALI.

摘要

石榴叶的水醇提取物先前已被证明在脂多糖（LPS）诱导的急性腹膜炎大鼠模型中具有抗炎作用。在这里，我们研究了从石榴叶水醇提取物中获得的乙酸乙酯馏分（EAFPg）对 LPS 诱导的急性肺损伤（ALI）小鼠模型的抗炎作用。雄性瑞士小鼠在 LPS 鼻腔内滴注前接受不同剂量的 EAFPg 或地塞米松（口服）。将接受载体治疗的小鼠用作对照。在 LPS 挑战后 4 小时处死动物，并收集支气管肺泡灌洗液（BALF）和肺样本进行分析。还研究了 EAFPg 和山柰酚对 LPS 刺激的 RAW 264.7 巨噬细胞中 NO 和细胞因子产生的影响。EAFPg（100-300mg/kg）预处理可显著减少 ALI 小鼠肺部的细胞积聚（特别是中性粒细胞）和胶原蛋白沉积。与载体对照相比，这些动物的肺和 BALF 中 TNF-α和 IL-1 的表达也降低（<0.05）。此外，EAFPg 或山柰酚（100μg/ml）孵育均可降低培养的 LPS 处理的 RAW 264.7 巨噬细胞中 NO 的产生和细胞因子基因表达。总的来说，这些结果表明 EAFPg 的预防性治疗可减轻急性肺炎症。我们认为该馏分可能对治疗 ALI 有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/5c8f8c41d335/JIR2018-6879183.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/d0d0b371d5dc/JIR2018-6879183.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/28bd839edce2/JIR2018-6879183.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/c0ee66707cb3/JIR2018-6879183.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/3b1394220d02/JIR2018-6879183.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/21a37623296d/JIR2018-6879183.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/99194d105f98/JIR2018-6879183.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/83771caab758/JIR2018-6879183.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/5c8f8c41d335/JIR2018-6879183.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/d0d0b371d5dc/JIR2018-6879183.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/28bd839edce2/JIR2018-6879183.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/c0ee66707cb3/JIR2018-6879183.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/3b1394220d02/JIR2018-6879183.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/21a37623296d/JIR2018-6879183.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/99194d105f98/JIR2018-6879183.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/83771caab758/JIR2018-6879183.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/5838491/5c8f8c41d335/JIR2018-6879183.008.jpg

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