Onu Justus Uchenna, Ohaeri Jude Uzoma
Department of Clinical Services, Federal Neuropsychiatric Hospital, New Haven, Enugu, Enugu State, Nigeria.
Department of Psychological Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
Niger Postgrad Med J. 2018 Jan-Mar;25(1):1-7. doi: 10.4103/npmj.npmj_190_17.
The debate on the current nosological status of schizophrenia and mood disorders as distinct entities is very active among scholars. There is a paucity of genetic epidemiological data to contribute an African perspective to this debate.
This study aimed to assess the morbid risk of mood disorders in the relatives of schizophrenia probands, in comparison with the families of a sample of healthy controls.
This study elicited the information on the morbid risk of mood disorders among 5259 relatives of schizophrenia probands (n = 138) and 6734 relatives of healthy controls (n = 138) through direct interview of patients, available relatives of patients and the comparison group. The family history approach using the Family Interview for Genetic Studies was utilised to obtain information on the morbid risk of all relatives that could be recalled. The diagnosis of available relatives was confirmed using the Diagnostic Interview for Genetic Studies. Morbid risk estimates were calculated using the Weinberg shorter method for age correction.
Morbid risk for mood disorders in the first-, second- and third-degree relatives of schizophrenia probands were 1.39% (95% confidence interval [CI] = 1.23-1.55), 0.86% (95% CI = 0.80-0.92) and 0.55% (95% CI = 0.53-0.57), respectively, compared with 0.45% (95% CI = 0.39-0.51), 0.11% (95% CI = 0.07-0.51) and 0.08% (95% CI = 0.06-0.09), respectively, for the healthy comparison group.
This result supports the impression that familial risk for mood disorders is significantly higher among relatives of schizophrenia patients, compared with healthy controls and that there could be familial relationship between the predisposition to schizophrenia and mood disorders.
关于精神分裂症和心境障碍作为不同实体的当前疾病分类学地位的争论在学者中非常活跃。缺乏能从非洲视角为这场争论提供依据的遗传流行病学数据。
本研究旨在评估精神分裂症先证者亲属中患心境障碍的患病风险，并与健康对照样本的家庭进行比较。
本研究通过直接访谈患者、患者的现有亲属以及对照组，收集了138名精神分裂症先证者的5259名亲属和138名健康对照者的6734名亲属中患心境障碍的患病风险信息。采用用于遗传研究的家族访谈的家族史方法，获取所有能回忆起来的亲属的患病风险信息。使用用于遗传研究的诊断访谈确认现有亲属的诊断。使用温伯格较短年龄校正方法计算患病风险估计值。
精神分裂症先证者的一级、二级和三级亲属中患心境障碍的患病风险分别为1.39%（95%置信区间[CI]=1.23 - 1.55）、0.86%（95%CI = 0.80 - 0.92）和0.55%（95%CI = 0.53 - 0.57），而健康对照组分别为0.45%（95%CI = 0.39 - 0.51）、0.11%（95%CI = 0.07 - 0.51）和0.08%（95%CI = 0.06 - 0.09）。
该结果支持以下观点，即与健康对照组相比，精神分裂症患者亲属中患心境障碍的家族风险显著更高，并且精神分裂症易感性与心境障碍之间可能存在家族关系。
