Sham P C, Gottesman I I, MacLean C J, Kendler K S
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Psychiatry Res. 1994 May;52(2):125-34. doi: 10.1016/0165-1781(94)90082-5.
Several recent studies have found a greater risk of schizophrenia among the relatives of female schizophrenic probands than the relatives of male schizophrenic probands. These results are contradictory to those of earlier studies. The current investigation, using family data collected in the 1950's and 1960's in Sweden, did not find a difference in the risk of schizophrenia among the relatives of male and female schizophrenic probands. However, significantly more relatives of female probands than relatives of male probands had manic-depressive psychosis. These findings suggest that the earlier studies may have included some female schizophrenic probands who would be classified as having manic-depression by modern criteria.
最近的几项研究发现，女性精神分裂症先证者的亲属患精神分裂症的风险比男性精神分裂症先证者的亲属更高。这些结果与早期研究的结果相矛盾。目前这项利用20世纪50年代和60年代在瑞典收集的家庭数据进行的调查，并未发现男性和女性精神分裂症先证者的亲属患精神分裂症的风险存在差异。然而，女性先证者的亲属患躁狂抑郁症的人数明显多于男性先证者的亲属。这些发现表明，早期研究可能纳入了一些按照现代标准会被归类为患有躁狂抑郁症的女性精神分裂症先证者。
