Onu Justus Uchenna, Ohaeri Jude Uzoma
Department of Mental Health, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
Department of Psychological Medicine, University of Nigeria, Nsukka, Enugu Campus, Enugu State, Nigeria.
Afr Health Sci. 2020 Jun;20(2):697-708. doi: 10.4314/ahs.v20i2.21.
The nature of the association between obstetric complications (OCs) at birth and the genetic aetiology of schizophrenia remains unclear, as some authors suggest that it is an independent risk factor while others support either interactionism or an epiphenomenon perspective.
To examine the association of family history of schizophrenia (FHS) with history of OCs, with a view to assessing whether this relationship moderates clinical phenotypes such as symptom dimensions and age at onset of illness.
This study examined OCs among schizophrenia probands using the Obstetric Complications Scale. An inquiry into family history was performed using the Family history method. Psychopathological symptom dimensions were assessed using standard scales. Data were analyzed to examine the interaction of FHS and history of OCs with age at onset and symptom dimensions, using ANCOVA.
FHS was significantly associated with the disorganized symptoms dimension (p=0.03). History of OCs was significantly associated with earlier age at onset (p=0.007). However, in ANCOVA, the effect of the interaction between FHS and history of OCs was not significant for age at onset and symptom dimensions (P = 0.059).
FHS was significantly associated with disorganization syndrome, and OCs was significantly associated with age at onset.
出生时产科并发症（OCs）与精神分裂症的遗传病因之间关联的本质仍不明确，因为一些作者认为它是一个独立的风险因素，而另一些人则支持交互作用论或附带现象论的观点。
研究精神分裂症家族史（FHS）与OCs病史之间的关联，以评估这种关系是否会影响临床表型，如症状维度和发病年龄。
本研究使用产科并发症量表对精神分裂症先证者的OCs进行检查。使用家族史方法对家族史进行调查。使用标准量表评估精神病理症状维度。采用协方差分析对数据进行分析，以检验FHS和OCs病史与发病年龄和症状维度之间的相互作用。
FHS与紊乱症状维度显著相关（p=0.03）。OCs病史与发病年龄较早显著相关（p=0.007）。然而，在协方差分析中，FHS和OCs病史之间的相互作用对发病年龄和症状维度的影响不显著（P = 0.059）。
FHS与紊乱综合征显著相关，OCs与发病年龄显著相关。
