Graduate School of Pharmaceutical Sciences , Nagoya City University , 3-1, Tanabe-Dori , Mizuho-ku, Nagoya 467-8603 , Aichi , Japan.
School of Pharmacy , Nihon University , 7-7-1, Narashinodai , Funabashi , 274-8555 , Chiba , Japan.
J Nat Prod. 2018 May 25;81(5):1143-1147. doi: 10.1021/acs.jnatprod.7b00627. Epub 2018 Apr 20.
12- epi-Lycopodine (1), a Lycopodium alkaloid, along with lycopodine (2) and huperzine A (3), were discovered in the mycelium of Paraboeremia sp. Lsl3KI076, a UV-irradiated strain of Paraboeremia sp. Lsl3, an endophytic fungus from Lycopodium serratum Thunb. var. longipetiolatum Spring. Additionally, a trace of 1 was isolated from Phlegmariurus nummulariifolius (Blume) Ching, and the structure was elucidated on the basis of spectroscopic data. This is the first report proving that a new naturally occurring Lycopodium alkaloid can be obtained from an endophytic fungus.
12- 表石松碱（1）是一种石松生物碱，与石松碱（2）和石杉碱甲（3）一起，从石松属内生真菌 Paraboeremia sp. Lsl3KI076 的菌丝体中被发现，该菌株是石松属 Paraboeremia sp. Lsl3 的 UV 诱变株，来源于石松 Lycopodium serratum Thunb. var. longipetiolatum Spring。此外，痕量的 1 从 Phlegmariurus nummulariifolius（Blume）Ching 中被分离出来，并基于光谱数据阐明了其结构。这是第一个证明一种新的天然存在的石松生物碱可以从内生真菌中获得的报告。
