Bergström S, Norrby K
Department of Pathology, University of Gothenburg, Sahlgren's Hospital, Sweden.
APMIS. 1988 May;96(5):407-14. doi: 10.1111/j.1699-0463.1988.tb05323.x.
Hyperplastic growth of the mesenterial windows abutting the small gut occurs in lactating rats (Bergström and Norrby 1988) and chronically diabetic rats (Norrby et al. 1983). In the present study, early events in the mesenterial windows and the small gut in streptozotocin-diabetic rats were examined. The area of the mesenterial windows had already increased significantly on day 1 and hyperplasia in terms of increased DNA content, as well as an increase in histamine content (a mast-cell marker), was established from day 2 of diabetes. The increase in total mesenterial window content of DNA, histamine and protein was roughly linear and parallel from day 2 to day 19. The small-gut circumference increased transiently on day 1, but the small-gut mucosal volume was unaffected on days 1 and 2. The small-gut wet weight increased significantly from day 5, whereas elongation was not observed until day 19. The difference in time between the appearance of hyperplasia and the growth of the mesenterial windows and their adjoining gut and the rate with which the hyperplasia proceeds in the two tissues indicate that the regulatory mechanisms of early hyperplastic growth in these tissues are not identical. The factor(s) causing mesenterial window growth and hyperplasia is/are as yet unknown.
在哺乳期大鼠（Bergström和Norrby，1988年）以及慢性糖尿病大鼠（Norrby等人，1983年）中，紧邻小肠的肠系膜窗会出现增生性生长。在本研究中，对链脲佐菌素诱导的糖尿病大鼠的肠系膜窗和小肠中的早期事件进行了检查。糖尿病第1天，肠系膜窗面积就已显著增加，从糖尿病第2天起，就出现了DNA含量增加以及组胺含量增加（肥大细胞标志物）的增生现象。从第2天到第19天，肠系膜窗DNA、组胺和蛋白质的总含量大致呈线性且平行增加。小肠周长在第1天短暂增加，但第1天和第2天小肠黏膜体积未受影响。小肠湿重从第5天起显著增加，而直到第19天才观察到伸长现象。增生出现的时间与肠系膜窗及其相邻肠道生长的时间差异，以及两个组织中增生进展的速率表明，这些组织早期增生性生长的调节机制并不相同。导致肠系膜窗生长和增生的因素尚不清楚。
