Schedl H P, Schwartz J, Wilson H D
Medical Service, Veterans Administration, Iowa City, Iowa.
Digestion. 1988;39(3):137-43. doi: 10.1159/000199617.
Depressed somatic growth in the rat with streptozotocin diabetes is associated with greatly enhanced intestinal growth. In patients with diabetes mellitus, growth hormone is elevated. Therefore, we measured the association between gut growth and serum growth hormone in the streptozotocin-diabetic rat. At 10 days growth hormone did not differ in control, untreated diabetic and insulin-treated diabetic groups. At 20 days of diabetes, growth hormone was elevated in untreated diabetic groups, but depressed to control levels by insulin. Intestinal growth was markedly elevated in all diabetic groups by 10 days, prior to the increases in hormone levels. We conclude that the enhanced intestinal growth in diabetes is probably independent of growth hormone.
链脲佐菌素诱导糖尿病大鼠的躯体生长受抑制，同时肠道生长显著增强。糖尿病患者体内生长激素水平升高。因此，我们测定了链脲佐菌素诱导糖尿病大鼠肠道生长与血清生长激素之间的关系。在第10天时，对照组、未治疗糖尿病组和胰岛素治疗糖尿病组的生长激素水平无差异。糖尿病20天时，未治疗糖尿病组的生长激素水平升高，但胰岛素治疗后降至对照水平。在激素水平升高之前，所有糖尿病组在第10天时肠道生长均显著增强。我们得出结论，糖尿病时肠道生长增强可能与生长激素无关。
