Adewara Bolajoko A, Adegbehingbe Bernice O, Onakpoya Oluwatoyin H, Ihemedu Chidi G
Ophthalmology Department, College of Heath Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Ophthalmology Department, Lily Hospitals Limited, Warri, Nigeria.
Int Ophthalmol. 2018 Apr;38(2):541-547. doi: 10.1007/s10792-017-0488-4. Epub 2017 Mar 13.
To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls.
A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer. LT and ACD were measured using A-scan ultrasonography and the IOLMaster, respectively. Data were analyzed using SPSS version 19.0 and level of significance set at p value <0.05.
In the glaucoma group and control groups, respectively, mean age was 60.3 ± 8.9 and 58.5 ± 8.1 years (p = 0.234), mean IOP was 28.27 ± 7.88 and 14.47 ± 2.60 mmHg (p < 0.001), mean ACD was 3.12 ± 0.27 and 3.15 ± 0.24 mm (p = 0.514), mean LT was 4.24 ± 0.46 and 4.23 ± 0.45 mm (p = 0.903), and mean ACD was shallower in females (p = 0.034) and (p = 0.001). In the glaucoma group, there was a positive correlation between IOP and ACD (r = 0.022, p = 0.864), but a negative correlation between IOP and LT (r = -0.04, p = 0.758) and ACD and LT (r = -0.058, p = 0.657). In the control group, there was a positive correlation between IOP and ACD (r = 0.141, p = 0.275), IOP and LT (r = 0.031, p = 0.811) and ACD and LT (r = 0.016, p = 0.901).
ACD is shallower in females. There is no significant correlation between IOP and ACD or between IOP and LT in POAG as well as normal individuals.
研究原发性开角型青光眼（POAG）患者的眼压（IOP）、前房深度（ACD）和晶状体厚度（LT）之间的关系，并与年龄和性别匹配的对照组进行比较。
在一家三级眼科诊所对62例新诊断的POAG患者和62例年龄和性别匹配的对照者进行横断面分析研究。记录社会人口统计学数据和眼部检查结果。使用Goldmann压平眼压计测量眼压。分别使用A超超声检查和IOLMaster测量晶状体厚度和前房深度。使用SPSS 19.0软件进行数据分析，显著性水平设定为p值<0.05。
青光眼组和对照组的平均年龄分别为60.3±8.9岁和58.5±8.1岁（p = 0.234），平均眼压分别为28.27±7.88 mmHg和14.47±2.60 mmHg（p < 0.001），平均前房深度分别为3.12±0.27 mm和3.15±0.24 mm（p = 0.514），平均晶状体厚度分别为4.24±0.46 mm和4.23±0.45 mm（p = 0.903），女性的平均前房深度较浅（p = 0.034）和（p = 0.001）。在青光眼组中，眼压与前房深度呈正相关（r = 0.022，p = 0.864），但眼压与晶状体厚度呈负相关（r = -0.04，p = 0.758），前房深度与晶状体厚度呈负相关（r = -0.058，p = 0.657）。在对照组中，眼压与前房深度呈正相关（r = 0.141，p = 0.275），眼压与晶状体厚度呈正相关（r = 0.031，p = 0.811），前房深度与晶状体厚度呈正相关（r = 0.016，p = 0.901）。
女性的前房深度较浅。在POAG患者以及正常个体中，眼压与前房深度或眼压与晶状体厚度之间均无显著相关性。
