Department of Medical Biotechnology, YeungNam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk, Republic of Korea.
Department of Medical Biotechnology, YeungNam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk, Republic of Korea.
Biomed Pharmacother. 2018 Jul;103:574-581. doi: 10.1016/j.biopha.2018.04.025. Epub 2018 Apr 24.
Bioactive peptides are actively involved in different biological functions and importantly contribute to human health, and the use of peptides as therapeutics has a long successful history in disease management. A number of peptides have wide-ranging therapeutic effects, such as antioxidant, antimicrobial, and antithrombotic effects. Neurodegenerative diseases are typically caused by abnormal aggregations of proteins or peptides, and the depositions of these aggregates in or on neurons, disrupt signaling and eventually kill neurons. During recent years, research on short peptides has advanced tremendously. This review offers a brief introduction to peptide based therapeutics and their application in disease management and provides an overview of peptide vaccines, and toxicity related issues. In addition, the importance of peptides in the management of different neurodegenerative diseases and their therapeutic applications is discussed. The present review provides an understanding of peptides and their applications for the management of different diseases, but with focus on neurodegenerative diseases. The role of peptides as anti-cancer, antimicrobial and antidiabetic agents has also been discussed.
生物活性肽在不同的生物学功能中发挥着积极的作用，对人类健康尤为重要，而肽类作为治疗药物在疾病管理方面有着悠久的成功历史。许多肽类具有广泛的治疗效果，如抗氧化、抗菌和抗血栓形成作用。神经退行性疾病通常是由蛋白质或肽的异常聚集引起的，这些聚集物在神经元内或神经元上的沉积会破坏信号传递，最终导致神经元死亡。近年来，对短肽的研究取得了巨大进展。本综述简要介绍了基于肽的治疗方法及其在疾病管理中的应用，并概述了肽疫苗以及与毒性相关的问题。此外，还讨论了肽在管理不同神经退行性疾病及其治疗应用中的重要性。本文综述提供了对肽及其在不同疾病管理中的应用的理解，但重点是神经退行性疾病。肽作为抗癌、抗菌和抗糖尿病药物的作用也已被讨论。
