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基于肽的蛋白质-蛋白质相互作用（PPI）抑制剂：以严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白与人血管紧张素转换酶2（hACE2）之间的相互作用为例

Peptide-Based Inhibitors of Protein-Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2).

作者信息

Rakhmetullina Aizhan, Zielenkiewicz Piotr, Odolczyk Norbert

机构信息

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.

Department of Systems Biology, Institute of Experimental Plant Biology and Biotechnology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

出版信息

Biomedicines. 2024 Oct 16;12(10):2361. doi: 10.3390/biomedicines12102361.

DOI:10.3390/biomedicines12102361
PMID:39457672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11504900/
Abstract

Protein-protein interactions (PPIs) are fundamental to many critical biological processes and are crucial in mediating essential cellular functions across diverse organisms, including bacteria, parasites, and viruses. A notable example is the interaction between the SARS-CoV-2 spike (S) protein and the human angiotensin-converting enzyme 2 (hACE2), which initiates a series of events leading to viral replication. Interrupting this interaction offers a promising strategy for blocking or significantly reducing infection, highlighting its potential as a target for anti-SARS-CoV-2 therapies. This review focuses on the hACE2 and SARS-CoV-2 spike protein interaction, exemplifying the latest advancements in peptide-based strategies for developing PPI inhibitors. We discuss various approaches for creating peptide-based inhibitors that target this critical interaction, aiming to provide potential treatments for COVID-19.

摘要

蛋白质-蛋白质相互作用（PPIs）对于许多关键的生物学过程至关重要，并且在介导包括细菌、寄生虫和病毒在内的各种生物体的基本细胞功能方面起着关键作用。一个显著的例子是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突（S）蛋白与人血管紧张素转换酶2（hACE2）之间的相互作用，该相互作用引发了一系列导致病毒复制的事件。中断这种相互作用为阻断或显著减少感染提供了一种有前景的策略，突出了其作为抗SARS-CoV-2治疗靶点的潜力。本综述重点关注hACE2与SARS-CoV-2刺突蛋白的相互作用，例证了基于肽的PPI抑制剂开发策略的最新进展。我们讨论了针对这种关键相互作用创建基于肽的抑制剂的各种方法，旨在为2019冠状病毒病（COVID-19）提供潜在的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552c/11504900/61cd9e3261ee/biomedicines-12-02361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552c/11504900/61cd9e3261ee/biomedicines-12-02361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552c/11504900/61cd9e3261ee/biomedicines-12-02361-g001.jpg

相似文献

[1]
Peptide-Based Inhibitors of Protein-Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2).

Biomedicines. 2024-10-16

[2]
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[3]
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[4]
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[5]
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[6]
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).

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[7]
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[8]
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[10]
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引用本文的文献

[1]
An engineered miniACE2 protein secreted by mesenchymal stromal cells effectively neutralizes multiple SARS-CoV- 2 variants in vitro.

Mol Med. 2025-4-23

[2]
Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells.

Front Microbiol. 2025-3-26

[3]
Interactomic Analyses and a Reverse Engineering Study Identify Specific Functional Activities of One-to-One Interactions of the S1 Subunit of the SARS-CoV-2 Spike Protein with the Human Proteome.

Biomolecules. 2024-12-3

本文引用的文献

[1]
A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19.

Antiviral Res. 2024-9

[2]
Outlook of pandemic preparedness in a post-COVID-19 world.

NPJ Vaccines. 2023-11-20

[3]
Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era.

Molecules. 2023-10-19

[4]
Strategies to improve the physicochemical properties of peptide-based drugs.

Pharm Res. 2023-3

[5]
Label-Free Analysis of Binding and Inhibition of SARS-Cov-19 Spike Proteins to ACE2 Receptor with ACE2-Derived Peptides by Surface Plasmon Resonance.

ACS Appl Bio Mater. 2023-1-16

[6]
A peptide array pipeline for the development of Spike-ACE2 interaction inhibitors.

Peptides. 2022-12

[7]
Improvement of native structure-based peptides as efficient inhibitors of protein-protein interactions of SARS-CoV-2 spike protein and human ACE2.

Front Mol Biosci. 2022-9-28

[8]
Harnessing the Therapeutic Potential and Biological Activity of Antiviral Peptides.

Chembiochem. 2022-10-19

[9]
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal.

J Biomed Sci. 2022-9-6

[10]
Small Molecules Targeting SARS-CoV-2 Spike Glycoprotein Receptor-Binding Domain.

ACS Omega. 2022-8-9

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