Akimoto K, Miyata A, Kangawa K, Koga Y, Hayakawa K, Matsuo H
Department of Pediatrics, Miyazaki Medical College, Japan.
J Clin Endocrinol Metab. 1988 Jul;67(1):93-7. doi: 10.1210/jcem-67-1-93.
To determine the molecular forms of atrial natriuretic peptide (ANP) in patients with cardiovascular disease, we analyzed the ANP content in the right atrium using reverse phase high performance liquid chromatography and RIA. Tissue from 35 patients, ranging in age from 1 month to 64 yr, was studied. The right atrial ANP content was high in patients with congestive heart failure regardless of age. We found three ANP components (alpha-, beta-, and gamma ANP), as previously found in tissue obtained at autopsy. In patients younger than 20 yr old, the major component was gamma ANP. In older patients, the frequency and content of the two low mol wt forms, especially beta ANP, were increased. The differences in the content and molecular forms of ANP in atrial tissue reflect the pathological state in patients with cardiovascular diseases, as well as the patient's age.
为了确定心血管疾病患者心房利钠肽（ANP）的分子形式，我们使用反相高效液相色谱法和放射免疫分析法分析了右心房中的ANP含量。研究了35例年龄从1个月到64岁的患者的组织。无论年龄大小，充血性心力衰竭患者的右心房ANP含量都很高。我们发现了三种ANP成分（α-、β-和γ-ANP），正如之前在尸检获得的组织中所发现的那样。在20岁以下的患者中，主要成分是γ-ANP。在老年患者中，两种低分子量形式，尤其是β-ANP的频率和含量增加。心房组织中ANP含量和分子形式的差异反映了心血管疾病患者的病理状态以及患者的年龄。
