Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Department of Medicine and Ageing Sciences, University G. D'Annunzio, Via dei Vestini 15, 66100, Chieti-Pescara, Italy.
J Assist Reprod Genet. 2018 Jul;35(7):1289-1294. doi: 10.1007/s10815-018-1185-6. Epub 2018 Apr 20.
Retrospective and cross-sectional studies suggested that non-O blood group may be associated with failures of in vitro fertilization (IVF), but data remain controversial. The aim of this observational cohort study was to prospectively evaluate the effect of non-O blood type on clinical outcomes of IVF.
Women < 40 years who underwent IVF and had ABO blood type recorded as part of the routine workup were eligible. The primary study outcome was live birth. Secondary outcomes included spontaneous abortion, positive pregnancy test, and clinical pregnancy.
A total of 497 women with a mean age of 34.6 (standard deviation 3.2) years were included. The mean number of embryos transferred was 2.3 (standard deviation 0.6). The most common ABO blood types were O (n = 213, 42.9%) and A (n = 203, 40.8%), while 63 (12.7%) and 18 (3.6%) women had the B and AB blood types, respectively. Differences in live birth (21.8 vs. 24.3%, odds ratio [OR] 1.17; 95% confidence intervals [CI], 0.76 to 1.78), positive pregnancy test (37.9 vs. 36.6%, OR 0.96; 95% CI, 0.66 to 1.38), clinical pregnancy (35.1 vs. 33.8%, OR 0.95; 95% CI, 0.66 to 1.39), and spontaneous abortion (12.3 vs. 9.2%, OR 0.72; 95% CI, 0.41 to 1.29) between women with O and non-O blood type were not statistically significant.
In a prospective cohort study, we confirmed the lack of a significant association between non-O blood type and clinical outcomes of IVF. Further studies are needed to clarify whether non-O blood group has any prognostic relevance in women undergoing IVF.
回顾性和横断面研究表明，非 O 血型可能与体外受精（IVF）失败有关，但数据仍存在争议。本观察性队列研究的目的是前瞻性评估非 O 血型对 IVF 临床结局的影响。
符合条件的是年龄<40 岁、接受 IVF 且 ABO 血型记录作为常规检查一部分的女性。主要研究结局为活产。次要结局包括自然流产、妊娠试验阳性和临床妊娠。
共纳入 497 名平均年龄 34.6（标准差 3.2）岁的女性。平均移植胚胎数为 2.3（标准差 0.6）。最常见的 ABO 血型为 O（n=213，42.9%）和 A（n=203，40.8%），B 型和 AB 型分别占 12.7%（n=63）和 3.6%（n=18）。活产率（21.8%比 24.3%，优势比[OR] 1.17；95%置信区间[CI]，0.76 至 1.78）、妊娠试验阳性率（37.9%比 36.6%，OR 0.96；95% CI，0.66 至 1.38）、临床妊娠率（35.1%比 33.8%，OR 0.95；95% CI，0.66 至 1.39）和自然流产率（12.3%比 9.2%，OR 0.72；95% CI，0.41 至 1.29）在 O 型和非 O 型血女性之间无统计学意义。
在一项前瞻性队列研究中，我们证实非 O 血型与 IVF 临床结局之间无显著相关性。需要进一步研究以阐明非 O 血型组在接受 IVF 的女性中是否具有任何预后相关性。
