Pereira Nigel, Patel Hency H, Stone Logan D, Christos Paul J, Elias Rony T, Spandorfer Steven D, Rosenwaks Zev
The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
Weill Cornell Medical College, New York, New York.
Fertil Steril. 2017 Nov;108(5):791-797. doi: 10.1016/j.fertnstert.2017.08.019. Epub 2017 Sep 15.
To investigate the association between ABO blood type and live-birth outcomes in patients undergoing IVF with day 5 single-embryo transfer (SET).
Retrospective cohort study.
University-affiliated center.
PATIENT(S): Normal responders, <40 years old, undergoing their first IVF cycle with fresh SET.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Live-birth rate was the primary outcome. Secondary outcomes were birth weight and gestational age at delivery. Univariate and multivariable logistic regression was used to examine the association between blood type and live birth, while controlling for confounders. Odds ratios (OR) with 95% confidence intervals (CI) for live birth were estimated.
RESULT(S): A total of 2,329 patients were included. The mean age of the study cohort was 34.6 ± 4.78 years. The distribution of blood types was as follows: A = 897 (38.5%); B = 397 (17.0%); AB = 120 (5.2%); and, O = 1,915 (39.3%) patients. There was no difference in the baseline demographics, ovarian stimulation, or embryo quality parameters between the blood types. The unadjusted ORs for live birth when comparing blood type A (referent) with blood types B, AB, and O were 0.96 (95% CI, 0.6-1.7), 0.72 (95% CI, 0.4-1.2), and 0.96 (95% CI. 0.6-1.7), respectively. The adjusted ORs for live birth remained not significant when comparing blood type A to blood types B, AB, and O individually. No difference in birth weight or gestational age at delivery was noted among the four blood types.
CONCLUSION(S): Our findings suggest that ABO blood type is not associated with live-birth rate, birth weight, or gestational age at delivery in patients undergoing IVF with day 5 SET.
探讨ABO血型与接受第5天单胚胎移植（SET）的体外受精（IVF）患者活产结局之间的关联。
回顾性队列研究。
大学附属医院中心。
年龄<40岁的正常反应者，正在进行首次新鲜SET的IVF周期。
无。
活产率是主要结局。次要结局是出生体重和分娩时的孕周。采用单因素和多因素逻辑回归分析来检验血型与活产之间的关联，同时控制混杂因素。估计活产的比值比（OR）及其95%置信区间（CI）。
共纳入2329例患者。研究队列的平均年龄为34.6±4.78岁。血型分布如下：A型=897例（38.5%）；B型=397例（17.0%）；AB型=120例（5.2%）；O型=1915例（39.3%）。各血型之间在基线人口统计学、卵巢刺激或胚胎质量参数方面无差异。将A型血（参照组）与B型、AB型和O型血进行比较时，活产的未调整OR分别为0.96（95%CI，0.6 - 1.
