阿奇霉素用于治疗种植体周围炎效果的随机临床试验。
Randomized clinical trial of the effects of azithromycin use in the treatment of peri-implantitis.
作者信息
Gershenfeld L, Kalos A, Whittle T, Yeung S
机构信息
Faculty of Dentistry, University of Sydney, Sydney, New South Wales, Australia.
Jaw Function Research Unit, Westmead Centre for Oral Health, University of Sydney, Sydney, New South Wales, Australia.
出版信息
Aust Dent J. 2018 Apr 21. doi: 10.1111/adj.12614.
BACKGROUND
The aim of this clinical trial was to establish a proof of concept that the adjunctive use of systemic azithromycin (AZM) in conjunction with mechanical debridement has an increased benefit in reducing soft tissue inflammation in the treatment of peri-implantitis.
METHODS
In a randomized, double-blind, clinical trial, the treatment group (nine patients) received AZM as well as mechanical debridement in a single course of treatment, whereas the control group (eight patients) received a placebo and mechanical debridement. The primary outcome variables studied were bleeding on probing, suppuration, pocket probing depth and gingival recession. The secondary variables studied were gingival index, plaque index, microbiological and interleukin-1β status. The observation period was 6 months.
RESULTS
Over the 6 months' observation period, the treatment patients showed a consistently greater reduction of gingival inflammation and an improvement in soft tissue healing than the control patients.
CONCLUSIONS
The adjunctive use of a single course of systemic azithromycin can assist in the control of peri-implant mucositis in the treatment of peri-implantitis.
背景
本临床试验的目的是建立一个概念验证，即全身应用阿奇霉素（AZM）联合机械清创术在治疗种植体周围炎时，在减轻软组织炎症方面具有更大的益处。
方法
在一项随机、双盲临床试验中，治疗组（9例患者）在单一疗程中接受AZM以及机械清创术，而对照组（8例患者）接受安慰剂和机械清创术。研究的主要结局变量为探诊出血、化脓、牙周袋探诊深度和牙龈退缩。研究的次要变量为牙龈指数、菌斑指数、微生物学和白细胞介素-1β状态。观察期为6个月。
结果
在6个月的观察期内，治疗组患者的牙龈炎症持续减轻，软组织愈合情况优于对照组患者。
结论
全身应用一个疗程的阿奇霉素辅助治疗可有助于控制种植体周围炎治疗中的种植体周围黏膜炎。
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