Laboratory of Pharmacology and Molecular Chemistry, Department of Biological Chemical, Regional University of Cariri, Cel Antonio Luis 1161, Pimenta, CEP 63105-000, Crato, CE, Brazil.
Leao Sampaio University Center, Juazeiro do Norte, CE, Brazil.
Food Chem Toxicol. 2018 Sep;119:199-205. doi: 10.1016/j.fct.2018.04.041. Epub 2018 Apr 20.
The aim of this study was to evaluate the anti-edematogenic activity of X. americana L. (HEXA) hydroethanolic extract in ear edema models (acute and chronic) induced by croton oil and by different phlogistic agents (arachidonic acid, capsaicin, phenol and histamine), identifying the possible anti-edematogenic mechanism. HEXA demonstrated a significant anti-edematogenic effect at concentrations of 100-500 μg/ear in ear edema induced by croton oil with higher inhibition of edema of 39.37. However, the concentrations of 100 and 200 μg/ear were taken as a standard, demonstrating the effect in the chronic model induced by croton oil with inhibition of 61.62% and 48.74%. In the AA-induced ear edema model, HEXA showed inhibition of: 24.45% and 32.31%; capsaicin inhibition of 72.72% and 47.57%; phenol inhibition of 34% and 20.1%; and histamine inhibition of 31.8% and 21.62%. Then, the results were showed that HEXA demonstrated an anti-edematogenic effect in acute and chronic inflammation models, demonstrating a probable mechanism of action by the inhibition or modulation of key mediators of the inflammatory process. The chemical profile and presence of flavonoids guaranteeing a profile of activity similar to natural drugs that act or modulate the production of mediators of inflammations.
本研究旨在评估美洲商陆（HEXA）水醇提取物在巴豆油和不同致炎剂（花生四烯酸、辣椒素、苯酚和组胺）诱导的耳肿胀模型（急性和慢性）中的抗水肿活性，确定可能的抗水肿机制。HEXA 在浓度为 100-500μg/耳时对巴豆油诱导的耳肿胀显示出显著的抗水肿作用，水肿抑制率高达 39.37%。然而，100 和 200μg/耳的浓度被视为标准，在巴豆油诱导的慢性模型中显示出 61.62%和 48.74%的抑制作用。在 AA 诱导的耳肿胀模型中，HEXA 显示出对以下物质的抑制作用：24.45%和 32.31%；辣椒素抑制率为 72.72%和 47.57%；苯酚抑制率为 34%和 20.1%；组胺抑制率为 31.8%和 21.62%。结果表明，HEXA 在急性和慢性炎症模型中表现出抗水肿作用，可能通过抑制或调节炎症过程中的关键介质来发挥作用。该化学特征和类黄酮的存在保证了与作用或调节炎症介质产生的天然药物相似的活性谱。
