Centro per le Malattie Tropicali, Ospedale Classificato Equiparato Sacro Cuore - Don Calabria, Negrar, Verona, Italy; Malattie Infettive, ASST Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
Centro per le Malattie Tropicali, Ospedale Classificato Equiparato Sacro Cuore - Don Calabria, Negrar, Verona, Italy.
Travel Med Infect Dis. 2018 Sep-Oct;25:31-34. doi: 10.1016/j.tmaid.2018.04.011. Epub 2018 Apr 20.
In non-endemic countries, one of the most important routes of transmission of Trypanosoma cruzi is vertical transmission. The objective of this work is to report the results of the screening activities for the control of congenital Chagas Disease (CD) implemented in Bergamo province between January 2014 and December 2016.
The programme addressed Bolivian pregnant women settled in Bergamo province. All the eight hospitals offering antenatal and delivery care in that area were involved. We retrospectively calculated the coverage rate of the screening programme, the prevalence of CD in this population, as well as transmission rate to their offspring.
During the study period, 376 Bolivian women accounted for 387 deliveries. The coverage rate of serologic screening was 85.6%. Confirmed seropositive women were 28, accounting for a prevalence of CD of 8.7% (95% IC 5.9-11.5). Among 29 children born to positive mothers, one infected child was detected (transmission rate of 4.3%, 95% IC 0-12.6) and treated accordingly. Other 13 children previously born from the same mothers were retrieved and tested for CD: no additional congenital cases were diagnosed.
Our screening programme presented a high coverage, although widely variable in the different birthing facilities. National guidelines recommending CD testing in pregnant women would help to increase case detection countrywide.
在非流行国家，克氏锥虫最重要的传播途径之一是垂直传播。本研究的目的是报告 2014 年 1 月至 2016 年 12 月在贝加莫省实施的先天性恰加斯病（CD）控制筛查活动的结果。
该项目针对定居在贝加莫省的玻利维亚孕妇。该地区提供产前和分娩护理的所有 8 家医院都参与了该项目。我们回顾性地计算了筛查计划的覆盖率、该人群中 CD 的流行率以及向其后代传播的比率。
在研究期间，376 名玻利维亚妇女共分娩 387 例。血清学筛查的覆盖率为 85.6%。确诊的阳性妇女有 28 例，CD 的患病率为 8.7%（95%置信区间为 5.9-11.5）。在 29 名阳性母亲所生的儿童中，检测到 1 名感染儿童（传播率为 4.3%，95%置信区间为 0-12.6）并进行了相应治疗。另外还检索并检测了来自同一母亲的 13 名先前出生的儿童，未发现其他先天性病例。
我们的筛查计划覆盖率很高，但在不同的分娩机构差异很大。国家指南建议对孕妇进行 CD 检测，这将有助于在全国范围内提高病例检出率。
