营养保健品在啮齿动物模型中作为治疗人类炎症性肠病的潜在方法。

Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease.

机构信息

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia; Functional Foods Research Group, Institute for Agriculture and the Environment, University of Southern Queensland, Toowoomba, QLD 4350, Australia.

Functional Foods Research Group, Institute for Agriculture and the Environment, University of Southern Queensland, Toowoomba, QLD 4350, Australia.

出版信息

Pharmacol Res. 2018 Jun;132:99-107. doi: 10.1016/j.phrs.2018.04.015. Epub 2018 Apr 20.

DOI:10.1016/j.phrs.2018.04.015

PMID:29680446

Abstract

Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of all or part of the digestive tract. Nutraceuticals include bioactive compounds such as polyphenols with anti-inflammatory activities, thus these products have the potential to treat chronic inflammatory diseases. We have emphasized the role of nutraceuticals in ameliorating the symptoms of IBD in rodent models of human IBD through modulation of key pathogenic mechanisms including dysbiosis, oxidative stress, increased inflammatory cytokines, immune system dysregulation, and inflammatory cell signaling pathways. Nutraceuticals have an important role in IBD patients as a preventive approach to extend remission phases and as a therapeutic intervention to suppress active IBD. Further clinical trials on nutraceuticals with positive results in rodent models are warranted.

摘要

炎症性肠病（IBD）的特征是消化道全部或部分的慢性炎症。营养保健品包括具有抗炎活性的生物活性化合物，如多酚，因此这些产品有可能治疗慢性炎症性疾病。我们强调了营养保健品通过调节关键致病机制，包括肠道菌群失调、氧化应激、促炎细胞因子增加、免疫系统失调和炎症细胞信号通路，在改善人类 IBD 啮齿动物模型中 IBD 症状方面的作用。营养保健品在 IBD 患者中具有重要作用，可作为预防措施延长缓解期，并作为治疗干预措施抑制活动性 IBD。有必要对在啮齿动物模型中取得积极结果的营养保健品进行进一步的临床试验。