Graduate School, Wuhan Sports University, Wuhan 430079, China; These authors contributed equally to this work.
Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China; These authors contributed equally to this work.
Trends Endocrinol Metab. 2018 Jun;29(6):380-388. doi: 10.1016/j.tem.2018.03.019. Epub 2018 Apr 18.
MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.
miR-143 是一种 miRNA，通过下调氧固醇结合蛋白相关蛋白 8（ORP8），特异性抑制胰岛素-AKT 通路，从而抑制 AKT 磷酸化、胰岛素耐受，并最终发展为 2 型糖尿病（T2DM）。有氧运动可通过下调 miR-143 来预防 T2DM。然而，运动引起的 miR-143 变化的潜在机制尚不清楚。在本研究中，我们将总结 miR-143 参与调节 T2DM 的发展以及潜在的诊断、预防和治疗机制，包括通过靶向 miR-143 进行运动干预治疗 T2DM。
