The Research Center for Animal Science, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan 739-8528.
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada T6G 2P5.
J Dairy Sci. 2018 Jul;101(7):6627-6631. doi: 10.3168/jds.2018-14412. Epub 2018 Apr 19.
Glucagon-like peptide (GLP)-1 is involved in glucose homeostasis via its role in stimulating insulin secretion, whereas GLP-2 increases mucosal growth of the small intestine. To our knowledge, the effect of delayed colostrum feeding on plasma GLP-1 and GLP-2 in neonatal calves has not been evaluated. To investigate the effect of delayed colostrum feeding on plasma concentrations of GLP-1 and GLP-2 in newborn calves, we randomly assigned 27 Holstein bull calves to 1 of 3 treatment groups: those fed colostrum within 1 h after birth (control), 6 h after birth (6H), and 12 h after birth (12H; n = 9 for each treatment). Blood samples were obtained before the colostrum feeding and every 3 h after each colostrum feeding for a 36-h period, and plasma concentrations of GLP-1, GLP-2, insulin, and glucose were measured. Plasma GLP-1 concentration at 12 h after colostrum feeding was lower in 12H than in control calves. In addition, plasma insulin concentration was lower in the 6H and 12H calves than in the controls. Plasma glucose and GLP-2 concentrations were, however, not affected by treatment. These results indicate that delayed colostrum feeding can decrease plasma GLP-1 and insulin concentrations without affecting glucose or GLP-2 concentration.
胰高血糖素样肽 (GLP)-1 通过刺激胰岛素分泌来参与葡萄糖稳态，而 GLP-2 则增加小肠的黏膜生长。据我们所知，延迟初乳喂养对新生牛犊血浆 GLP-1 和 GLP-2 的影响尚未得到评估。为了研究延迟初乳喂养对新生牛犊血浆 GLP-1 和 GLP-2 浓度的影响，我们将 27 头荷斯坦公牛犊随机分为 3 个处理组之一：出生后 1 小时内（对照组）、6 小时（6H）和 12 小时（12H）内喂养初乳（每组 9 头）。在初乳喂养前和每次初乳喂养后每 3 小时采集血液样本，持续 36 小时，并测量血浆 GLP-1、GLP-2、胰岛素和葡萄糖浓度。在初乳喂养后 12 小时，12H 组的血浆 GLP-1 浓度低于对照组。此外，6H 和 12H 组的血浆胰岛素浓度低于对照组。然而，血浆葡萄糖和 GLP-2 浓度不受处理影响。这些结果表明，延迟初乳喂养会降低血浆 GLP-1 和胰岛素浓度，而不会影响葡萄糖或 GLP-2 浓度。
